Publication Date:
2010-11-19
Description:
Abstract 2646 Chronic transfusions are the only treatment validated to reduce the stroke risk in children with SCD whose velocity at transcranial doppler (TCD) is ≥ 200 cm/sec. This treatment has potential risks and its optimal duration is not known. In order to evaluate the potential role of HU for primary stroke prevention, we reviewed the time-averaged maximum velocities (TAMV) measured by TCD in the middle cerebral arteries and the magnetic resonance angiographies (MRA) of SCD patients aged from 1 to 25 years and followed in our institution between 1993 and 2008. In 124 patients (65 females and 59 males) screened by TCD for the first time at a mean age of 7.1±5.3 years, we found that in patients not treated by HU at the time of first TCD (n=68), the TAMV was higher in patients aged from 2 to 5 years (203±37 cm/sec, n= 34, p
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine
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