ISSN:
1750-3841
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
: Pleurocidin, an antimicrobial peptide originally isolated from the winter flounder (Pleuronecetes americanus),was evaluated for potential use in food application. Eighteen microbial species, including yeasts, molds, and foodborne bacterial pathogens, were evaluated. Liquid-based minimal inhibitory concentration (MIC) technique was used to test antimicrobial activity of the synthetic peptide. Hemolytic and cytotoxic effects on human cells were investigated using colorimetric analysis. Pleurocidin was found to be effective against foodborne organisms including Vibrio parahemolyticus(MIC of 69 μM), Escherichia coliO157:H7 (5.3 μM), Listeria monocytogenes(23 μM), Saccharomyces cerevisiae(5.5 μM), and Penicillium expansum(20.6 μM). Antimicrobial activity occurred without significant hemolytic or cytotoxic effect on human intestinal cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2621.2004.tb13373.x
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