Publication Date:
2014-11-12
Description:
A novel metal-free strategy for a rapid and α-selctive C-alkynylation of glycals was developed. The reaction utilizes TMSOTf as a promoter to generate in situ trimethylsilylacetylene for C-alkynylation. Thanks to this methodology, we can access C-glycosides in a single step from a variety of acetylenes , i.e., arylacetylenes and most importantly aliphatic alkynes.
Print ISSN:
2195-951X
Electronic ISSN:
1860-5397
Topics:
Chemistry and Pharmacology
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