Publication Date:
1980-09-19
Description:
Two unstable mutations at the his4 locus of yeast are due to the insertion of the transposable elements Ty912 and Ty917 into the his4 regulatory region. The two transposons are related, one being derived from the other by a substitution of 4000 base pairs of DNA. Element Ty912 includes identical terminal repeats, whereas the terminal repeats of Ty917 are not identical. Transposition of Ty912 or Ty917 generates 5-base-pair duplications of the target DNA at either end of the element. Expression and reversion of a his4 gene containing Ty912 or Ty917 is controlled by three unlinked regulatory genes. The properties of these regulatory genes are similar to those described for the controlling elements in maize.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roeder, G S -- Farabaugh, P J -- Chaleff, D T -- Fink, G R -- CA23441/CA/NCI NIH HHS/ -- GM07617/GM/NIGMS NIH HHS/ -- GM15408/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1980 Sep 19;209(4463):1375-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6251544" target="_blank"〉PubMed〈/a〉
Keywords:
Alleles
;
Base Sequence
;
Cloning, Molecular/methods
;
*DNA Transposable Elements
;
DNA, Fungal/genetics
;
Genes, Regulator
;
Genetic Linkage
;
Histidine/*genetics
;
Saccharomyces cerevisiae/*genetics
;
Suppression, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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