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  • 1
    Publication Date: 2015-04-30
    Description: The response of a laminar premixed methane-air flame subjected to flow perturbations around a steady state is examined experimentally and using a linearized compressible Navier-Stokes solver with a one-step chemistry mechanism to describe combustion. The unperturbed flame takes an M-shape stabilized both by a central bluff body and by the external rim of a cylindrical nozzle. This base flow is computed by a nonlinear direct simulation of the steady reacting flow, and the flame topology is shown to qualitatively correspond to experiments conducted under comparable conditions. The flame is then subjected to acoustic disturbances produced at different locations in the numerical domain, and its response is examined using the linearized solver. This linear numerical model then allows the componentwise investigation of the effects of flow disturbances on unsteady combustion and the feedback from the flame on the unsteady flow field. It is shown that a wrinkled reaction layer produces hydrodynamic disturbances in the fresh reactant flow field that superimpose on the acoustic field. This phenomenon, observed in several experiments, is fully interpreted here. The additional perturbations convected by the mean flow stem from the feedback of the perturbed flame sheet dynamics onto the flow field by a mechanism similar to that of a perturbed vortex sheet. The different regimes where this mechanism prevails are investigated by examining the phase and group velocities of flow disturbances along an axis oriented along the main direction of the flow in the fresh reactant flow field. It is shown that this mechanism dominates the low-frequency response of the wrinkled shape taken by the flame and, in particular, that it fully determines the dynamics of the flame tip from where the bulk of noise is radiated.
    Print ISSN: 1070-6631
    Electronic ISSN: 1089-7666
    Topics: Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2012-12-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sipp, Douglas -- Turner, Leigh -- New York, N.Y. -- Science. 2012 Dec 7;338(6112):1296-7. doi: 10.1126/science.1229918.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉RIKEN Center for Developmental Biology, Kobe 12345, Japan. sipp@cdb.riken.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23224541" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Products ; Commerce ; Consumer Product Safety/*legislation & jurisprudence ; *Federal Government ; *Guidelines as Topic ; Humans ; Mesenchymal Stromal Cells ; Safety ; Stem Cell Transplantation/*legislation & jurisprudence ; *Stem Cells ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2013-08-24
    Description: The neural crest is a transient population of migratory cells in the embryo that gives rise to a wide variety of different cell types, including those of the peripheral nervous system. Dysfunction of neural crest cells (NCCs) is associated with multiple diseases, such as neuroblastoma and Hirschsprung disease. Recent studies have identified NCC behaviors during their migration and differentiation, with implications for their contributions to development and disease. Here, we describe how interactions between cells of the neural crest and lineages such as the vascular system, as well as those involving environmental signals and microbial pathogens, are critically important in determining the roles played by these cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takahashi, Yoshiko -- Sipp, Douglas -- Enomoto, Hideki -- New York, N.Y. -- Science. 2013 Aug 23;341(6148):860-3. doi: 10.1126/science.1230717.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, Graduate School of Science, Kyoto University, Kitashirakawa, Sakyo-ku, Kyoto 606-8502, Japan. yotayota@develop.zool.kyoto-u.ac.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23970693" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aorta/cytology/embryology ; Cell Communication ; Cell Lineage ; *Cell Movement ; Chick Embryo ; Child ; Hirschsprung Disease/pathology ; Humans ; Intestines/*cytology/*innervation ; Multipotent Stem Cells/*physiology ; Neural Crest/*cytology ; Neuroblastoma/pathology ; Neuronal Plasticity ; Parasympathetic Nervous System/*cytology ; Schwann Cells/pathology/physiology ; Sympathetic Nervous System/*cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2013-03-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Swan, Alma -- Cockerill, Matthew -- Sipp, Douglas -- England -- Nature. 2013 Mar 28;495(7442):442-3. doi: 10.1038/495442a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23538813" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information/*legislation & jurisprudence ; *Consumer Advocacy ; Costs and Cost Analysis ; Internet/utilization ; Public Policy ; Public Sector/*economics ; Publishing/*economics/trends ; *Research/economics ; Time Factors ; Translating
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 5
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    Nature Publishing Group (NPG)
    Publication Date: 2014-06-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bianco, Paolo -- Sipp, Douglas -- England -- Nature. 2014 Jun 19;510(7505):336-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24955467" target="_blank"〉PubMed〈/a〉
    Keywords: Cell- and Tissue-Based Therapy/economics/ethics/standards/trends ; *Ethics, Business ; *Government Regulation ; Humans ; Stem Cell Transplantation/ethics/legislation & jurisprudence ; Terminally Ill
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kiatpongsan, Sorapop -- Sipp, Douglas -- New York, N.Y. -- Science. 2009 Mar 20;323(5921):1564-5. doi: 10.1126/science.1168451.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand 10330.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19299604" target="_blank"〉PubMed〈/a〉
    Keywords: Health Facilities/*standards ; Humans ; *Internationality ; Patient Advocacy ; Stem Cell Transplantation/standards ; *Stem Cells ; Therapeutics/*standards
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2016-05-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Caulfield, Timothy -- Sipp, Douglas -- Murry, Charles E -- Daley, George Q -- Kimmelman, Jonathan -- New York, N.Y. -- Science. 2016 May 13;352(6287):776-7. doi: 10.1126/science.aaf4620. Epub 2016 May 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Health Law Institute, University of Alberta, Edmonton, Alberta T6G 2H5, Canada. caulfield@ualberta.ca. ; Riken Center for Developmental Biology, Kobe, Japan, 650-0047. Keio University School of Medicine, Tokyo, Japan, 160-8582. ; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA. ; Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. ; STREAM research group, Biomedical Ethics Unit, McGill University, Montreal, Quebec H3A 1X1, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27174977" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2016-05-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kimmelman, Jonathan -- Hyun, Insoo -- Benvenisty, Nissim -- Caulfield, Timothy -- Heslop, Helen E -- Murry, Charles E -- Sipp, Douglas -- Studer, Lorenz -- Sugarman, Jeremy -- Daley, George Q -- England -- Nature. 2016 May 12;533(7603):311-3. doi: 10.1038/533311a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉McGill University, Montreal, Canada, and a member of the steering committee of the International Society for Stem Cell Research's Guidelines Task Force. ; Case Western Reserve University School of Medicine, USA, and a member of the steering committee of the International Society for Stem Cell Research's Guidelines Task Force. ; Azrieli Center for Stem Cells and Genetic Research, Hebrew University, Jerusalem, Israel, and a member of the steering committee of the International Society for Stem Cell Research's Guidelines Task Force. ; Canada Research Chair in Health Law and Policy at the University of Alberta, Canada, and a member of the steering committee of the International Society for Stem Cell Research's Guidelines Task Force. ; Center for Cell and Gene Therapy at Baylor College of Medicine in Houston, Texas, USA, and a member of the steering committee of the International Society for Stem Cell Research's Guidelines Task Force. ; Departments of Pathology, Bioengineering and Medicine/Cardiology, University of Washington, Seattle, Washington, USA, and a member of the steering committee of the International Society for Stem Cell Research's Guidelines Task Force. ; RIKEN Center for Developmental Biology, Kobe, Japan, project professor at Keio University School of Medicine, Tokyo, Japan, and a member of the steering committee of the International Society for Stem Cell Research's Guidelines Task Force. ; Developmental Biology Program and director of the Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, USA, and a member of the steering committee of the International Society for Stem Cell Research's Guidelines Task Force. ; Berman Institute of Bioethics and Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA, and a member of the steering committee of the International Society for Stem Cell Research's Guidelines Task Force. ; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA, and a member of the steering committee of the International Society for Stem Cell Research's Guidelines Task Force.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27193661" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2014-06-13
    Description: The dynamics of the Lamb-Chaplygin dipole in the large-wavelength limit is investigated by means of linear analysis. Taking the three-dimensional spectrum of the Lamb-Chaplygin dipole calculated by Billant [“Three-dimensional stability of a vortex pair,” Phys. Fluids11, 2069 (1999)] as a reference, we first show that additional families of unstable modes are present in the spectrum. Among them, a family of symmetric modes and one of antisymmetric modes, both present in the large-wavelength limit, are the main topic of this investigation. The most unstable modes in these two families being purely two-dimensional, the two-dimensional dynamics is more particularly investigated. Our calculations show that the amplification rate of the antisymmetric instability is significantly larger than that of the symmetric instability. Also, while the two-dimensional symmetric mode is stationary and induces a shift of the dipole toward the upstream or downstream direction relatively to the dipole self-propagation velocity vector, the antisymmetric mode is unsteady and displaces the dipole into wavy oscillations about its initial straight trajectory. The leading physical mechanism of these two-dimensional instabilities is the vortex shedding that occurs downstream of the dipole. This shedding is the reaction of the external flow to the dipole motion and basically enables the conservation of the flow impulse. The destabilizing action of the wake is amplified as the displaced dipole generates more shedding. The dipole motion and the wake thus reinforce each other, leading to the instability. The strain mutually exerted by the vortices of the dipole, known as an essential mechanism of three-dimensional vortex pair instabilities, is also shown to participate to this destabilization.
    Print ISSN: 1070-6631
    Electronic ISSN: 1089-7666
    Topics: Physics
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  • 10
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 10 (1998), S. 839-849 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The aim of the present paper is to study three-dimensional elliptic instability in two-dimensional flattened Taylor–Green vortices, which constitutes a model problem for the topics of wake vortex dynamics. Shortwave asymptotics and classical linear stability theory are developed. Both approaches show that the flow is unstable. In particular, the structure of the most amplified growing mode is the same as that obtained in unbounded elliptical flows. The limits of the linear regime and the effects of the nonlinear interactions are characterized by means of a spectral Direct Numerical Simulation (DNS). © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
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