Publication Date:
2012-03-31
Description:
The structure of the brain as a product of morphogenesis is difficult to reconcile with the observed complexity of cerebral connectivity. We therefore analyzed relationships of adjacency and crossing between cerebral fiber pathways in four nonhuman primate species and in humans by using diffusion magnetic resonance imaging. The cerebral fiber pathways formed a rectilinear three-dimensional grid continuous with the three principal axes of development. Cortico-cortical pathways formed parallel sheets of interwoven paths in the longitudinal and medio-lateral axes, in which major pathways were local condensations. Cross-species homology was strong and showed emergence of complex gyral connectivity by continuous elaboration of this grid structure. This architecture naturally supports functional spatio-temporal coherence, developmental path-finding, and incremental rewiring with correlated adaptation of structure and function in cerebral plasticity and evolution.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773464/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773464/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wedeen, Van J -- Rosene, Douglas L -- Wang, Ruopeng -- Dai, Guangping -- Mortazavi, Farzad -- Hagmann, Patric -- Kaas, Jon H -- Tseng, Wen-Yih I -- P41 RR-023953/RR/NCRR NIH HHS/ -- P41 RR-14075/RR/NCRR NIH HHS/ -- P41 RR014075/RR/NCRR NIH HHS/ -- P41 RR023953/RR/NCRR NIH HHS/ -- R01 EY002686/EY/NEI NIH HHS/ -- R01 MH064044/MH/NIMH NIH HHS/ -- R01 NS016446/NS/NINDS NIH HHS/ -- R01-MH652456/MH/NIMH NIH HHS/ -- U01 MH093765/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2012 Mar 30;335(6076):1628-34. doi: 10.1126/science.1215280.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Radiology, Massachusetts General Hospital (MGH), Harvard Medical School and the MGH/Massachussetts Institute of Technology, Charlestown, MA 02129, USA. van@nmr.mgh.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22461612" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Aotidae
;
Axons/ultrastructure
;
Biological Evolution
;
Brain Mapping
;
Callithrix
;
Cerebral Cortex/*anatomy & histology/embryology/ultrastructure
;
Diffusion Magnetic Resonance Imaging
;
Galago
;
Humans
;
Image Processing, Computer-Assisted
;
Imaging, Three-Dimensional
;
Macaca mulatta
;
*Nerve Fibers
;
Neural Pathways/*anatomy & histology/embryology/ultrastructure
;
Prosencephalon/anatomy & histology/ultrastructure
;
Species Specificity
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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