Publication Date:
2001-03-17
Description:
Caenorhabditis elegans oocytes, like those of most animals, arrest during meiotic prophase. Sperm promote the resumption of meiosis (maturation) and contraction of smooth muscle-like gonadal sheath cells, which are required for ovulation. We show that the major sperm cytoskeletal protein (MSP) is a bipartite signal for oocyte maturation and sheath contraction. MSP also functions in sperm locomotion, playing a role analogous to actin. Thus, during evolution, MSP has acquired extracellular signaling and intracellular cytoskeletal functions for reproduction. Proteins with MSP-like domains are found in plants, fungi, and other animals, suggesting that related signaling functions may exist in other phyla.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, M A -- Nguyen, V Q -- Lee, M H -- Kosinski, M -- Schedl, T -- Caprioli, R M -- Greenstein, D -- CA09592/CA/NCI NIH HHS/ -- GM57173/GM/NIGMS NIH HHS/ -- GM58008/GM/NIGMS NIH HHS/ -- HD07043/HD/NICHD NIH HHS/ -- HD25614/HD/NICHD NIH HHS/ -- R01 GM057173/GM/NIGMS NIH HHS/ -- R01 HD025614/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2001 Mar 16;291(5511):2144-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11251118" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Caenorhabditis elegans/*physiology
;
Carrier Proteins/chemistry/physiology
;
Cytoskeleton/chemistry/physiology
;
Disorders of Sex Development
;
Enzyme Activation
;
Evolution, Molecular
;
Female
;
Gonads/cytology/physiology
;
Helminth Proteins/chemistry/immunology/pharmacology/*physiology
;
MAP Kinase Signaling System
;
Male
;
*Meiosis
;
Membrane Proteins/chemistry/physiology
;
Microinjections
;
Mitogen-Activated Protein Kinases/metabolism
;
Molecular Sequence Data
;
Oocytes/*physiology
;
Ovulation
;
Phylogeny
;
Protein Folding
;
Protein Structure, Tertiary
;
Pseudopodia/physiology
;
Recombinant Proteins/pharmacology
;
Signal Transduction
;
Sperm Motility
;
Spermatozoa/chemistry/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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