Publication Date:
1996-08-23
Description:
Glutamate and aspartate are endogenous excitatory amino acid neurotransmitters widely distributed in the mammalian central nervous system. Aspartate was shown to induce a large membrane current sensitive to N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists in Purkinje cells from mice lacking functional NMDA receptors (NR1(-/-)). This response was accompanied by high permeability to calcium. In contrast, no current was induced by aspartate in hippocampal neurons and cerebellar granule cells from NR1(-/-) mice. Several other glutamate receptor agonists failed to evoke this response. Thus, in Purkinje cells, aspartate activates a distinct response capable of contributing to synaptic plasticity through calcium permeability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yuzaki, M -- Forrest, D -- Curran, T -- Connor, J A -- P30CA21765/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1996 Aug 23;273(5278):1112-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105-2794, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8688099" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Aspartic Acid/*pharmacology
;
Calcium/*metabolism
;
Cerebellum/cytology/metabolism
;
Excitatory Amino Acid Agonists/pharmacology
;
Excitatory Amino Acid Antagonists/pharmacology
;
Glutamic Acid/pharmacology
;
Hippocampus/cytology/metabolism
;
Homocysteine/analogs & derivatives/pharmacology
;
Magnesium/pharmacology
;
Mice
;
Mice, Knockout
;
N-Methylaspartate/pharmacology
;
Neuronal Plasticity
;
Neurons/drug effects/metabolism
;
Patch-Clamp Techniques
;
Permeability
;
Purkinje Cells/drug effects/*metabolism
;
Receptors, Amino Acid/drug effects/*metabolism
;
Receptors, N-Methyl-D-Aspartate/agonists/antagonists & inhibitors/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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