Publication Date:
1983-08-05
Description:
A decreased noradrenaline turnover in the hypothalami of rats was observed at the peak of the immune response to sheep red blood cells. The decrease in noradrenergic neuronal activity was mimicked by injection of soluble r mediators released by immunological cells activated in vitro. Noradrenaline also tended to decrease in the brainstem but not in the residual brain. It is suggested that products released from activated immunological cells during the immune response may induce the previously described autonomic and endocrine mechanisms that contribute to immunoregulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Besedovsky, H -- del Rey, A -- Sorkin, E -- Da Prada, M -- Burri, R -- Honegger, C -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):564-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867729" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Brain/*immunology/physiology
;
Brain Stem/immunology/physiology
;
Female
;
Hypothalamus/immunology/physiology
;
*Immunity
;
Norepinephrine/*physiology
;
Rats
;
Sheep/immunology
;
Spleen/immunology/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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