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Kinetics and subcellular distribution of S35-taurine uptake in rat cerebral cortex slices

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Zusammenfassung

Die Kinetik der Aufnahme von S35-Taurin in Rattencortex-Schnittchen wird im Konzentrationsbereich von 9×10−8M bis 5×10−3M untersucht. Nach Abzug des Transportes durch Diffusion (KD×S) findet man einen Mechanismus, der Michaelis-Menten Kinetik folgt (vsat), mitKm=1,73×10−4M. Ein solcher Transport liegt nicht im Bereich des spezifischen «uptake» der Neurotransmitter. Auch die sehr niedrige Aufnahme-Rate und die subzelluläre Verteilung nach «uptake» sprechen gegen eine Neurotransmitter-Funktion von Taurin.

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Literatur

  1. A. N. Davison andL. K. Kaczmarek, Nature, Lond.234, 107 (1971).

    Article  CAS  PubMed  Google Scholar 

  2. L. K. Kaczmarek andA. N. Davison, J. Neurochem.19, 2355 (1972).

    Article  CAS  PubMed  Google Scholar 

  3. L. L. Iversen andM. J. Neal, J. Neurochem.15, 1141 (1968);L. L. Iversen andG. A. R. Johnston, J. Neurochem.18, 1939 (1971);G. A. R. Johnston andL. L. Iversen, J. Neurochem.18, 1951 (1971);W. J. Logan andS. H. Snyder, Brain Res.42, 413 (1972);P. A. Bond, J. Neurochem.20, 511 (1973).

    Article  CAS  PubMed  Google Scholar 

  4. P. Lähdesmäki andS. S. Oja, Expl. Brain Res.15, 430 (1972).

    Article  Google Scholar 

  5. P. Lähdesmäki andS. S. Oja, J. Neurochem.20, 1411 (1973).

    Article  PubMed  Google Scholar 

  6. C. G. Honegger, L. M. Krepelka, M. Steiner andH. P. von Hahn, Experientia29, 752 (1973).

    Article  Google Scholar 

  7. C. G. Honegger, L. M. Krepelka andV. Steinmann, Experientia27, 728 (1971).

    Google Scholar 

  8. G. A. R. Johnston andL. L. Iversen J. Neurochem.18, 1951 (1971).

    Article  CAS  PubMed  Google Scholar 

  9. M. K. Gaitonde,Handbook of Neurochemistry (Ed.A. Lajtha; Plenum Press, New York 1970), vol.3, chapter 8, p. 225.

    Google Scholar 

  10. H. Pasantes-Morales, J. Klethi, M. Ledig andP. Mandel, Brain Res.41, 494 (1972).

    Article  CAS  PubMed  Google Scholar 

  11. H. Pasantes-Morales, J. Klethi, M. Ledig andP. Mandel, Physiol. Chem. Phys.4, 339 (1972).

    CAS  PubMed  Google Scholar 

  12. D. R. Curtis andJ. C. Watkins, Pharmac. Rev.17, 347 (1965);H. L. Haas andL. Hösli, Brain Res.52, 399 (1973).

    CAS  Google Scholar 

  13. H. Pasantes-Morales, P. F. Urban, J. Klethi andP. Mandel Brain Res.51, 375 (1973).

    Article  CAS  PubMed  Google Scholar 

  14. S. S. Oja, M. L. Karvonen andP. Lähdesmäki, Brain Res.55, 173 (1973).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Abteilung Neurochemie, Neurologische Universitätsklinik, Socinstrassc 55, CH-4051, Basel, Switzerland

    C. G. Honegger, M. Steiner & H. P. von Hahn

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  1. C. G. Honegger
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  2. L. M. Krepelka
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  3. M. Steiner
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  4. H. P. von Hahn
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Honegger, C.G., Krepelka, L.M., Steiner, M. et al. Kinetics and subcellular distribution of S35-taurine uptake in rat cerebral cortex slices. Experientia 29, 1235–1237 (1973). https://doi.org/10.1007/BF01935092

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