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  • 1
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    Specific inhibition of Stat3 signal transduction by PIAS3 (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-12-31
    Description: The signal transducer and activator of transcription-3 (Stat3) protein is activated by the interleukin 6 (IL-6) family of cytokines, epidermal growth factor, and leptin. A protein named PIAS3 (protein inhibitor of activated STAT) that binds to Stat3 was isolated and characterized. The association of PIAS3 with Stat3 in vivo was only observed in cells stimulated with ligands that cause the activation of Stat3. PIAS3 blocked the DNA-binding activity of Stat3 and inhibited Stat3-mediated gene activation. Although Stat1 is also phosphorylated in response to IL-6, PIAS3 did not interact with Stat1 or affect its DNA-binding or transcriptional activity. The results indicate that PIAS3 is a specific inhibitor of Stat3.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chung, C D -- Liao, J -- Liu, B -- Rao, X -- Jay, P -- Berta, P -- Shuai, K -- AI39612/AI/NIAID NIH HHS/ -- T32CA09056/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1997 Dec 5;278(5344):1803-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Chemistry, University of California, Los Angeles, CA 90095, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9388184" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Carrier Proteins/chemistry/genetics/*metabolism/pharmacology ; Cell Line ; DNA/metabolism ; DNA-Binding Proteins/genetics/*metabolism ; Gene Expression Regulation ; Humans ; Interferon Regulatory Factor-1 ; Interferon-alpha/pharmacology ; Interleukin-6/pharmacology ; *Intracellular Signaling Peptides and Proteins ; Mice ; Molecular Sequence Data ; NF-kappa B/metabolism ; Phosphoproteins/genetics ; Phosphorylation ; Phosphotyrosine/metabolism ; Protein Inhibitors of Activated STAT ; Recombinant Fusion Proteins/pharmacology ; STAT1 Transcription Factor ; STAT3 Transcription Factor ; *Signal Transduction ; Trans-Activators/*metabolism ; Transcriptional Activation ; Transfection ; Tumor Cells, Cultured ; Tumor Necrosis Factor-alpha/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Inhibition of Stat1-mediated gene activation by PIAS1 (1998)
    National Academy of Sciences
    Details
    Publication Date: 1998-09-01
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 3
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    Climate and height growth of taiwania (Taiwania cryptomerioides) and Taiwan incense-cedar (Calocedrus formosana) in Taiwan (2016)
    Oxford University Press
    In: Forestry
    Details
    Publication Date: 2016-08-27
    Description: Taiwan incense-cedar ( Calocedrus formosana (Florin) Florin) and taiwania ( Taiwania cryptomerioides Hayata) are coniferous species growing in Taiwan, Republic of China. Both species are red listed, and hence, their management and conservation are important. The objective of this research was to determine the effect of climate on the height growth of Taiwan incense-cedar and taiwania. Height growth data for Taiwan incense-cedar came from stem analysis data and the data for taiwania were from three sets of experimental plots. Climate data were obtained from nearby climate stations. Dynamic height growth models having parameters that were functions of climate variables were fit to the height data. A Chapman–Richards function formed the basis for Taiwan incense-cedar model, and a linear model was fit to the taiwania data. Mean summer temperature and precipitation were predictor variables for Taiwan incense-cedar height growth. These variables, along with growing degree-days, were predictor variables for taiwania. Several scenarios were devised to show the effect of climate on height growth. Under the A1B climate change scenario, the height growth of taiwania is expected to increase, but the height growth of Taiwan incense-cedar will decrease slightly. The climate/height growth relationships can assist in the conservation and stewardship of these species.
    Print ISSN: 0015-752X
    Electronic ISSN: 1464-3626
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Oxford University Press
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  • 4
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    ROCSAT-1 telecommunication experiments (1993)
    In:  CASI
    Details
    Publication Date: 2013-08-31
    Description: This paper addresses a telecommunication payload project approved by the R.O.C. NSPO's ROCSAT-1 space program. This project will enable several innovative experiments via the low-earth-orbit satellite ROCSAT-1, including multipath fading channel characterization, ionospheric scintillation measurement, real-time voice communications, and CDMA data communications. A unified L/S-band transponder payload is proposed for conducting these experiments in an efficient way. The results of these experiments would provide the evolving mobile communication communities with fruitful information.
    Keywords: COMMUNICATIONS AND RADAR
    Type: JPL, Proceedings of the Third International Mobile Satellite Conference (IMSC 1993); p 199-204
    Format: application/pdf
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    NASA TECHNICAL REPORTS
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