Publication Date:
2015-07-16
Description:
Key Points Oncogenic tyrosine kinase NPM-ALK binds to and phosphorylates STAT1, thereby promoting its proteasome-/STAT3-dependent degradation. STAT1 tumor suppressor effects in ALK+ ALCL include creating a STAT1/interferon-γ loop and interfering with STAT3 transcriptional activities.
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine
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