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  • 1
    Electronic Resource
    Electronic Resource
    Production and Role of Nitric Oxide in the Alveolar Immune Response to Pneumocystis carinii (2001)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 48 (2001), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.2001.tb00503.x
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  • 2
    Electronic Resource
    Electronic Resource
    A General Class of Confidence Interval (1946)
    [s.l.] : Nature Publishing Group
    Nature 158 (1946), S. 521-521 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] AMONG types of statistical inference about unknown parameters statements are possible which have a statistical truth, that is, they are random variables such that within the statistical framework adopted the probability of their being in error is known. In these statements intervals, called by ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/158521a0
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  • 3
    Electronic Resource
    Electronic Resource
    Determination of Plant Densities (1948)
    [s.l.] : Nature Publishing Group
    Nature 162 (1948), S. 621-621 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] E. J. MACHIN1 appears to be unaware of the extensive study by G. E. Blackman2 on the relation between plant density and percentage absence. In a theoretical appendix to this paper, I have pointed out that the most efficient size of quadrat corresponds to about 20 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/162621a0
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  • 4
    Electronic Resource
    Electronic Resource
    The β-tubulin gene from rat and human isolates of Pneumocystis carinii (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 6 (1992), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The development of new drugs for treating Pneumocystis carinii infections in AIDS patients is hampered by the lack of long-term culture systems, and by our generally limited knowledge of this organism. Recently, however, we observed significant activity of various benzimidazoles against growth of this organism in short-term cultures. Benzimidazoles inhibit microtubule polymerization; there is strong evidence that the primary target is the β-tubulin subunit. To understand the basis for benzimidazole activity against P. carinii, and to examine the apparent relatedness of this organism to fungi, we have cloned and sequenced the single β-tubulin gene from a rat P. carinii isolate. There was 89-91% identity at the amino acid level to β-tubulins from filamentous fungi, but only 79-82% identity to yeast and protozoal β-tubulins. Also, eight introns were distributed throughout the P. cariniiβ-tubulin gene in a pattern characteristic of filamentous fungi. Specific residues previously implicated in benzimidazole sensitivity were conserved in P. cariniiβ-tubulin. The polymerase chain reaction was used to amplify a segment of P. cariniiβ-tubulin DNA from bronchoalveolar lavages obtained from two patients with AIDS. There was considerable divergence at the DNA level between the human and rat sequences, but 100% identity at the ammo-acid level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1992.tb02204.x
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  • 5
    Electronic Resource
    Electronic Resource
    Recurrence Times (1950)
    [s.l.] : Nature Publishing Group
    Nature 165 (1950), S. 727-728 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] For any stationary process (that is, in statistical equilibrium) with a finite number of possible states, we may define a 'lifetime' t and a 'recurrence time' for any specified state *\ Chandrasekhar's method of deriving the complete distribution for t (chapter 3) applies to any Markqff ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/165727b0
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  • 6
    Electronic Resource
    Electronic Resource
    Combining the Probabilities from Significance Tests (1964)
    [s.l.] : Nature Publishing Group
    Nature 202 (1964), S. 731-731 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/202731a0
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  • 7
    Electronic Resource
    Electronic Resource
    An Asymptotic Theory for Dams (1964)
    [s.l.] : Nature Publishing Group
    Nature 202 (1964), S. 731-732 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Suppose water is coming into the dam at a rate equivalent to an additive process I(t) and is leaving independently equivalent to an additive process J(t). Let the capacity of the dam be C and let the initial volume of water at t = 0 be c. If the dam becomes full, the surplus water overflows and is ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/202731c0
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  • 8
    Electronic Resource
    Electronic Resource
    “Least-squares” Estimation of Distribution Mixtures (1968)
    [s.l.] : Nature Publishing Group
    Nature 217 (1968), S. 195-196 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the case of further unknown parameters j the problem is obviously more complex, because of the non-linear dependence of/ on j; but linearization of the estimation equations may sometimes be convenient. For example, for two populations with unknown parameters 1, 2 respectively, we might adopt the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/217195b0
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  • 9
    Electronic Resource
    Electronic Resource
    Asymptotic Dam Theory (1966)
    [s.l.] : Nature Publishing Group
    Nature 212 (1966), S. 326-326 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] As before, let the total capacity of the dam be C and the initial content c. Suppose the water lost before the dam first reaches emptiness be W, and let H(a|c) = E(eaW\c), where E denotes expectation. For the simple discrete case with probability p of one unit input and q of one unit output, we ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/212326a0
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  • 10
    Electronic Resource
    Electronic Resource
    Probability and Prejudice (1969)
    [s.l.] : Nature Publishing Group
    Nature 221 (1969), S. 786-786 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR,Professor Lindley (Nature, 221, 594; 1969) is, like Matthew, entitled to his opinion, but I do not see that his comments in any way dispose of my criticisms. First of all, perhaps I could protest at the irrelevant remarks in his first paragraph, which includes an inaccurate reporting of what I ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/221786b0
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