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  • 1
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    Adipsin and complement factor D activity: an immune-related defect in obesity (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-06-23
    Description: Adipsin is a serine protease that is secreted by adipocytes into the bloodstream; it is deficient in several animal models of obesity, representing a striking example of defective gene expression in this disorder. Recombinant mouse adipsin was purified and its biochemical and enzymatic properties were studied in order to elucidate the function of this protein. Activated adipsin has little or no proteolytic activity toward most substrates but has the same activity as human complement factor D, cleaving complement factor B when it is complexed with activated complement component C3. Like authentic factor D, adipsin can activate the alternative pathway of complement, resulting in red blood cell lysis. Decreased (58 to 80 percent) complement factor D activity, relative to lean controls, was observed as a common feature of several experimental models of obesity, including the ob/ob, db/db, and monosodium glutamate (MSG)-injected mouse and the fa/fa rat. These results suggest that adipsin and the alternative pathway of complement may play an unexpected but important role in the regulation of systemic energy balance in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosen, B S -- Cook, K S -- Yaglom, J -- Groves, D L -- Volanakis, J E -- Damm, D -- White, T -- Spiegelman, B M -- DK31403/DK/NIDDK NIH HHS/ -- DK34605/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1989 Jun 23;244(4911):1483-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Dana-Farber Cancer Institute, Boston, MA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2734615" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue/metabolism ; Amino Acid Sequence ; Animals ; Cell Line ; Complement Activating Enzymes/*metabolism ; Complement Factor D/*metabolism ; Complement Pathway, Alternative ; Cricetinae ; DNA/genetics ; Gene Expression Regulation ; Humans ; Immunoblotting ; Mice ; Molecular Sequence Data ; Obesity/genetics/*immunology/metabolism ; RNA, Messenger/metabolism ; Recombinant Proteins ; Serine Endopeptidases/genetics/isolation & purification/*metabolism ; Substrate Specificity ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Dopamine D1 signaling organizes network dynamics underlying working memory (2016)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2016-06-05
    Description: Local prefrontal dopamine signaling supports working memory by tuning pyramidal neurons to task-relevant stimuli. Enabled by simultaneous positron emission tomography–magnetic resonance imaging (PET-MRI), we determined whether neuromodulatory effects of dopamine scale to the level of cortical networks and coordinate their interplay during working memory. Among network territories, mean cortical D 1 receptor densities differed substantially but were strongly interrelated, suggesting cross-network regulation. Indeed, mean cortical D 1 density predicted working memory–emergent decoupling of the frontoparietal and default networks, which respectively manage task-related and internal stimuli. In contrast, striatal D 1 predicted opposing effects within these two networks but no between-network effects. These findings specifically link cortical dopamine signaling to network crosstalk that redirects cognitive resources to working memory, echoing neuromodulatory effects of D 1 signaling on the level of cortical microcircuits.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    F-14A aircraft high-speed flow simulations (1985)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: A model of the Grumman/Navy F-14A aircraft was developed for analyses using the NASA/Grumman Transonic Wing-Body Code. Computations were performed for isolated wing and wing fuselage glove arrangements to determine the extent of aerodynamic interference effects which propagate outward onto the main wing outer panel. Additional studies were conducted using the full potential analysis, FLO 22, to calibrate any inaccuracies that might accrue because of small disturbance code limitations. Comparisons indicate that the NASA/Grumman code provides excellent flow simulations for the range of wing sweep angles and flow conditions that will be of interest for the upcoming F-14 Variable Sweep Flight Transition Experiment.
    Keywords: AERODYNAMICS
    Type: NASA-CR-172559 , NAS 1.26:172559
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 4
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    The COREL and W12SC3 computer programs for supersonic wing design and analysis (1983)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: Two computer codes useful in the supersonic aerodynamic design of wings, including the supersonic maneuver case are described. The nonlinear full potential equation COREL code performs an analysis of a spanwise section of the wing in the crossflow plane by assuming conical flow over the section. A subsequent approximate correction to the solution can be made in order to account for nonconical effects. In COREL, the flow-field is assumed to be irrotional (Mach numbers normal to shock waves less than about 1.3) and the full potential equation is solved to obtain detailed results for the leading edge expansion, supercritical crossflow, and any crossflow shockwaves. W12SC3 is a linear theory panel method which combines and extends elements of several of Woodward's codes, with emphasis on fighter applications. After a brief review of the aerodynamic theory used by each method, the use of the codes is illustrated with several examples, detailed input instructions and a sample case.
    Keywords: AERODYNAMICS
    Type: NASA-CR-3676 , NAS 1.26:3676
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 5
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    Transonic analysis of canted winglets (1984)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: A computational method developed to provide a transonic analysis for upper/lower surface wing-tip mounted winglets is described. Winglets with arbitrary planform, cant and toe angle, and airfoil section can be modeled. The embedded grid approach provides high flow field resolution and the required geometric flexibility. In particular, coupled Cartesian/cylindrical grid systems are used to model the complex geometry presented by canted upper/lower surface winglets. A new rotated difference scheme is introduced in order to maintain the stability of the small-disturbance formulation in the presence of large spanwise velocities. Wing and winglet viscous effects are modeled using a two-dimensional 'strip' boundary layer analysis. Correlations with wind tunnel and flight test data for three transport configurations are included.
    Keywords: AERODYNAMICS
    Type: AIAA PAPER 84-0302
    Format: text
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    NASA TECHNICAL REPORTS
  • 6
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    Computational transonic analysis of canted winglets (1984)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Keywords: AERODYNAMICS
    Type: Journal of Aircraft (ISSN 0021-8669); 21; 873-878
    Format: text
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    NASA TECHNICAL REPORTS
  • 7
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    Two Programs for Supersonic Wing Design and Analysis (1986)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: COREL and W12SC3 useful in aerodynamic design and analysis of wings for supersonic speeds. COREL (Conical Relaxation) program solves nonlinear full potential equation for spanwise section of wing in crossflow plane, and option exists to correct result for nonconical geometry. W12SC3 applies lineartheory panel methods to compute solutions for wing/body configuration. Programs restricted to supersonic flows and useful for many design, analysis, and optimization applications. COREL and W12SC3 written in FORTRAN IV for batch execution.
    Keywords: MACHINERY
    Type: LAR-13239 , NASA Tech Briefs (ISSN 0145-319X); 10; 2; P. 106
    Format: text
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    NASA TECHNICAL REPORTS
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