ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    BCL2L1 and DLC1 as drug targets for gastric cancer [Medical Sciences] (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-10-07
    Description: Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide. Recent high-throughput analyses of genomic alterations revealed several driver genes and altered pathways in GC. However, therapeutic applications from genomic data are limited, largely as a result of the lack of druggable molecular targets and preclinical models for...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Genome sequence of Thellungiella salsuginea [Plant Biology] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-07-25
    Description: Thellungiella salsuginea, a close relative of Arabidopsis, represents an extremophile model for abiotic stress tolerance studies. We present the draft sequence of the T. salsuginea genome, assembled based on ∼134-fold coverage to seven chromosomes with a coding capacity of at least 28,457 genes. This genome provides resources and evidence about the nature of defense mechanisms constituting the genetic basis underlying plant abiotic stress tolerance. Comparative genomics and experimental analyses identified genes related to cation transport, abscisic acid signaling, and wax production prominent in T. salsuginea as possible contributors to its success in stressful environments.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Harmonic Pulse Testing for Well Monitoring: Application to a Fractured Geothermal Reservoir (2019)
    Wiley
    Details
    Publication Date: 2019
    Description: Abstract Harmonic Pulse Testing (HPT) has been developed as a type of well testing applicable during ongoing field operations because a pulsed signal is superimposed on background pressure trend. Its purpose is to determine well and formation parameters such as wellbore storage, skin, permeability, and boundaries within the investigated volume. Compared to conventional well testing, HPT requires more time to investigate the same reservoir volume. The advantage is that it does not require the interruption of well and reservoir injection/production before and/or during the test because it allows the extraction of an interpretable periodic signal from measured pressure potentially affected by interference. This makes it an ideal monitoring tool. Interpretation is streamlined through diagnostic plots mimicking conventional well test interpretation methods. To this end, analytical solutions in the frequency domain are available. The methodology was applied to monitor stimulation operations performed at an Enhanced Geothermal System site in Pohang, Korea. The activities were divided into two steps: first, a preliminary sequence of tests, injection/fall‐off, and two HPTs, characterized by low injection rates and dedicated to estimate permeability prior to stimulation operations, and then stimulation sequence characterized by a higher injection rate. During the stimulation operations other HPT were performed to monitor formation properties behavior. The interpretation of HPT data through the derivative approach implemented in the frequency domain provided reliable results in agreement with the injection test. Moreover, it provided an estimation of hydraulic properties without cessation of stimulation operations, thus confirming the effectiveness of HPT application for monitoring purposes.
    Print ISSN: 0043-1397
    Electronic ISSN: 1944-7973
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Published by Wiley on behalf of American Geophysical Union (AGU).
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    High-Q surface-plasmon-polariton whispering-gallery microcavity (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-01-23
    Description: Surface plasmon polaritons (SPPs) are electron density waves excited at the interfaces between metals and dielectric materials. Owing to their highly localized electromagnetic fields, they may be used for the transport and manipulation of photons on subwavelength scales. In particular, plasmonic resonant cavities represent an application that could exploit this field compression to create ultrasmall-mode-volume devices. A key figure of merit in this regard is the ratio of cavity quality factor, Q (related to the dissipation rate of photons confined to the cavity), to cavity mode volume, V (refs 10, 11). However, plasmonic cavity Q factors have so far been limited to values less than 100 both for visible and near-infrared wavelengths. Significantly, such values are far below the theoretically achievable Q factors for plasmonic resonant structures. Here we demonstrate a high-Q SPP whispering-gallery microcavity that is made by coating the surface of a high-Q silica microresonator with a thin layer of a noble metal. Using this structure, Q factors of 1,376 +/- 65 can be achieved in the near infrared for surface-plasmonic whispering-gallery modes at room temperature. This nearly ideal value, which is close to the theoretical metal-loss-limited Q factor, is attributed to the suppression and minimization of radiation and scattering losses that are made possible by the geometrical structure and the fabrication method. The SPP eigenmodes, as well as the dielectric eigenmodes, are confined within the whispering-gallery microcavity and accessed evanescently using a single strand of low-loss, tapered optical waveguide. This coupling scheme provides a convenient way of selectively exciting and probing confined SPP eigenmodes. Up to 49.7 per cent of input power is coupled by phase-matching control between the microcavity SPP and the tapered fibre eigenmodes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Min, Bumki -- Ostby, Eric -- Sorger, Volker -- Ulin-Avila, Erick -- Yang, Lan -- Zhang, Xiang -- Vahala, Kerry -- England -- Nature. 2009 Jan 22;457(7228):455-8. doi: 10.1038/nature07627.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Thomas J. Watson Laboratory of Applied Physics, California Institute of Technology, Pasadena, California 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19158793" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    A terahertz metamaterial with unnaturally high refractive index (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-02-19
    Description: Controlling the electromagnetic properties of materials, going beyond the limit that is attainable with naturally existing substances, has become a reality with the advent of metamaterials. The range of various structured artificial 'atoms' has promised a vast variety of otherwise unexpected physical phenomena, among which the experimental realization of a negative refractive index has been one of the main foci thus far. Expanding the refractive index into a high positive regime will complete the spectrum of achievable refractive index and provide more design flexibility for transformation optics. Naturally existing transparent materials possess small positive indices of refraction, except for a few semiconductors and insulators, such as lead sulphide or strontium titanate, that exhibit a rather high peak refractive index at mid- and far-infrared frequencies. Previous approaches using metamaterials were not successful in realizing broadband high refractive indices. A broadband high-refractive-index metamaterial structure was theoretically investigated only recently, but the proposed structure does not lend itself to easy implementation. Here we demonstrate that a broadband, extremely high index of refraction can be realized from large-area, free-standing, flexible terahertz metamaterials composed of strongly coupled unit cells. By drastically increasing the effective permittivity through strong capacitive coupling and decreasing the diamagnetic response with a thin metallic structure in the unit cell, a peak refractive index of 38.6 along with a low-frequency quasi-static value of over 20 were experimentally realized for a single-layer terahertz metamaterial, while maintaining low losses. As a natural extension of these single-layer metamaterials, we fabricated quasi-three-dimensional high-refractive-index metamaterials, and obtained a maximum bulk refractive index of 33.2 along with a value of around 8 at the quasi-static limit.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Choi, Muhan -- Lee, Seung Hoon -- Kim, Yushin -- Kang, Seung Beom -- Shin, Jonghwa -- Kwak, Min Hwan -- Kang, Kwang-Young -- Lee, Yong-Hee -- Park, Namkyoo -- Min, Bumki -- England -- Nature. 2011 Feb 17;470(7334):369-73. doi: 10.1038/nature09776.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-751, South Korea.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21331038" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    The architecture of Tetrahymena telomerase holoenzyme (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-04-05
    Description: Telomerase adds telomeric repeats to chromosome ends using an internal RNA template and a specialized telomerase reverse transcriptase (TERT), thereby maintaining genome integrity. Little is known about the physical relationships among protein and RNA subunits within a biologically functional holoenzyme. Here we describe the architecture of Tetrahymena thermophila telomerase holoenzyme determined by electron microscopy. Six of the seven proteins and the TERT-binding regions of telomerase RNA (TER) have been localized by affinity labelling. Fitting with high-resolution structures reveals the organization of TERT, TER and p65 in the ribonucleoprotein (RNP) catalytic core. p50 has an unanticipated role as a hub between the RNP catalytic core, p75-p19-p45 subcomplex, and the DNA-binding Teb1. A complete in vitro holoenzyme reconstitution assigns function to these interactions in processive telomeric repeat synthesis. These studies provide the first view of the extensive network of subunit associations necessary for telomerase holoenzyme assembly and physiological function.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817743/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817743/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jiang, Jiansen -- Miracco, Edward J -- Hong, Kyungah -- Eckert, Barbara -- Chan, Henry -- Cash, Darian D -- Min, Bosun -- Zhou, Z Hong -- Collins, Kathleen -- Feigon, Juli -- AI069015/AI/NIAID NIH HHS/ -- F32 GM101874/GM/NIGMS NIH HHS/ -- GM007185/GM/NIGMS NIH HHS/ -- GM071940/GM/NIGMS NIH HHS/ -- GM101874/GM/NIGMS NIH HHS/ -- GM48123/GM/NIGMS NIH HHS/ -- GM54198/GM/NIGMS NIH HHS/ -- R01 GM048123/GM/NIGMS NIH HHS/ -- R01 GM054198/GM/NIGMS NIH HHS/ -- R01 GM071940/GM/NIGMS NIH HHS/ -- England -- Nature. 2013 Apr 11;496(7444):187-92. doi: 10.1038/nature12062. Epub 2013 Apr 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California 90095, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23552895" target="_blank"〉PubMed〈/a〉
    Keywords: Catalytic Domain ; Holoenzymes/chemistry/genetics/ultrastructure ; Microscopy, Electron ; Models, Molecular ; Nucleic Acid Conformation ; Pliability ; Protein Structure, Tertiary ; Protein Subunits/analysis/chemistry/metabolism ; Protozoan Proteins/chemistry/metabolism/ultrastructure ; RNA/chemistry/metabolism/ultrastructure ; Ribonucleoproteins/chemistry/genetics/metabolism/ultrastructure ; Telomerase/*chemistry/genetics/metabolism/*ultrastructure ; Tetrahymena thermophila/chemistry/*enzymology/genetics/ultrastructure
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    Computational modelling of flow through prosthetic heart valves using the entropic lattice-Boltzmann method (2014)
    Cambridge University Press
    Details
    Publication Date: 2014-03-03
    Description: Previous clinical, in vitro experimental and in silico simulation studies have shown the complex dynamics of flow through prosthetic heart valves. In the case of bileaflet mechanical heart valves (BMHVs), complex flow phenomena are observed due to the presence of two rigid leaflets. A numerical method for this type of study must be able to accurately simulate pulsatile flow through BMHVs with the inclusion of leaflet motion and high-Reynolds-number flow modelling. Consequently, this study aims at validating a numerical method that captures the flow dynamics for pulsatile flow through a BMHV. A 23 mm St. Jude Medical (SJM) Regent™Â valve is selected for use in both the experiments and numerical simulations. The entropic lattice-Boltzmann method is used to simulate pulsatile flow through the valve with the inclusion of reverse leakage flow, while prescribing the flowrate and leaflet motion from experimental data. The numerical simulations are compared against experimental digital particle image velocimetry (DPIV) results from a previous study for validation. The numerical method is shown to match well with the experimental results quantitatively as well as qualitatively. Simulations are performed with efficient parallel processing at very high spatiotemporal resolution that can capture the finest details in the pulsatile BMHV flow field. This study validates the lattice-Boltzmann method as suitable for simulating pulsatile, high-Reynolds-number flows through prosthetic devices for use in future research. © 2014 Cambridge University Press.
    Print ISSN: 0022-1120
    Electronic ISSN: 1469-7645
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Published by Cambridge University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    Highly resolved pulsatile flows through prosthetic heart valves using the entropic lattice-Boltzmann method (2014)
    Cambridge University Press
    Details
    Publication Date: 2014-07-30
    Description: Prosthetic heart valves have been widely used to replace diseased or defective native heart valves. Flow through bileaflet mechanical heart valves (BMHVs) have previously demonstrated complex phenomena in the vicinity of the valve owing to the presence of two rigid leaflets. This study aims to accurately capture the complex flow dynamics for pulsatile flow through a 23 mm St Jude Medical (SJM) Regent™ BMHV. The lattice-Boltzmann method (LBM) is used to simulate pulsatile flow through the valve with the inclusion of reverse leakage flow at very high spatiotemporal resolution that can capture fine details in the pulsatile BMHV flow field. For higher-Reynolds-number flows, this high spatiotemporal resolution captures features that have not been observed in previous coarse resolution studies. In addition, the simulations are able to capture with detail the features of leaflet closing and the asymmetric b-datum leakage jet during mid-diastole. Novel flow physics are visualized and discussed along with quantification of turbulent features of this flow, which is made possible by this parallelized numerical method.
    Print ISSN: 0022-1120
    Electronic ISSN: 1469-7645
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Published by Cambridge University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Fermi surface reconstruction in CeTe2induced by charge density waves investigated via angle resolved photoemission (2012)
    American Physical Society
    Details
    Publication Date: 2012-02-10
    Print ISSN: 1098-0121
    Electronic ISSN: 1550-235X
    Topics: Physics
    Published by American Physical Society
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    Angle-resolved and resonant photoemission spectroscopy study of the Fermi surface reconstruction in the charge density wave systemsCeTe2andPrTe2 (2015)
    American Physical Society
    Details
    Publication Date: 2015-03-24
    Print ISSN: 1098-0121
    Electronic ISSN: 1550-235X
    Topics: Physics
    Published by American Physical Society
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...