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  • 1
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    SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-03-06
    Description: Sirtuins are NAD(+)-dependent protein deacetylases. They mediate adaptive responses to a variety of stresses, including calorie restriction and metabolic stress. Sirtuin 3 (SIRT3) is localized in the mitochondrial matrix, where it regulates the acetylation levels of metabolic enzymes, including acetyl coenzyme A synthetase 2 (refs 1, 2). Mice lacking both Sirt3 alleles appear phenotypically normal under basal conditions, but show marked hyperacetylation of several mitochondrial proteins. Here we report that SIRT3 expression is upregulated during fasting in liver and brown adipose tissues. During fasting, livers from mice lacking SIRT3 had higher levels of fatty-acid oxidation intermediate products and triglycerides, associated with decreased levels of fatty-acid oxidation, compared to livers from wild-type mice. Mass spectrometry of mitochondrial proteins shows that long-chain acyl coenzyme A dehydrogenase (LCAD) is hyperacetylated at lysine 42 in the absence of SIRT3. LCAD is deacetylated in wild-type mice under fasted conditions and by SIRT3 in vitro and in vivo; and hyperacetylation of LCAD reduces its enzymatic activity. Mice lacking SIRT3 exhibit hallmarks of fatty-acid oxidation disorders during fasting, including reduced ATP levels and intolerance to cold exposure. These findings identify acetylation as a novel regulatory mechanism for mitochondrial fatty-acid oxidation and demonstrate that SIRT3 modulates mitochondrial intermediary metabolism and fatty-acid use during fasting.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841477/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841477/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hirschey, Matthew D -- Shimazu, Tadahiro -- Goetzman, Eric -- Jing, Enxuan -- Schwer, Bjoern -- Lombard, David B -- Grueter, Carrie A -- Harris, Charles -- Biddinger, Sudha -- Ilkayeva, Olga R -- Stevens, Robert D -- Li, Yu -- Saha, Asish K -- Ruderman, Neil B -- Bain, James R -- Newgard, Christopher B -- Farese, Robert V Jr -- Alt, Frederick W -- Kahn, C Ronald -- Verdin, Eric -- DK019514-29/DK/NIDDK NIH HHS/ -- DK59637/DK/NIDDK NIH HHS/ -- K01 DK076573/DK/NIDDK NIH HHS/ -- K08 AG022325/AG/NIA NIH HHS/ -- K08 AG022325-01A1/AG/NIA NIH HHS/ -- P01 HL068758/HL/NHLBI NIH HHS/ -- P01 HL068758-06A1/HL/NHLBI NIH HHS/ -- P30 DK026743/DK/NIDDK NIH HHS/ -- P30 DK026743-26A1/DK/NIDDK NIH HHS/ -- R01 DK019514/DK/NIDDK NIH HHS/ -- R01 DK019514-29/DK/NIDDK NIH HHS/ -- R01 DK067509/DK/NIDDK NIH HHS/ -- R01 DK067509-04/DK/NIDDK NIH HHS/ -- U24 DK059637/DK/NIDDK NIH HHS/ -- U24 DK059637-01/DK/NIDDK NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2010 Mar 4;464(7285):121-5. doi: 10.1038/nature08778.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20203611" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Acyl-CoA Dehydrogenase, Long-Chain/chemistry/*metabolism ; Adenosine Triphosphate/biosynthesis/metabolism ; Adipose Tissue, Brown/enzymology/metabolism ; Animals ; Body Temperature Regulation ; Caloric Restriction ; Carnitine/analogs & derivatives/metabolism ; Cell Line ; Cold Temperature ; Fasting/metabolism ; Fatty Acids/*metabolism ; Humans ; Hypoglycemia/metabolism ; Liver/enzymology/metabolism ; Male ; Mass Spectrometry ; Mice ; Mitochondria/*enzymology/*metabolism ; Oxidation-Reduction ; Sirtuin 3/deficiency/genetics/*metabolism ; Triglycerides/metabolism ; Up-Regulation
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-11-05
    Description: B7 delivers a costimulatory signal through CD28, resulting in interleukin-2 secretion and T cell proliferation. Blockade of this pathway results in T cell anergy. The in vivo role of B7 was evaluated with B7-deficient mice. These mice had a 70 percent decrease in costimulation of the response to alloantigen. Despite lacking B7 expression, activated B cells from these mice bound CTLA-4 and GL1 monoclonal antibody, demonstrating that alternative CTLA-4 ligand or ligands exist. These receptors are functionally important because the residual allogenic mixed lymphocyte responses were blocked by CTLA4Ig. Characterization of these CTLA-4 ligands should lead to strategies for manipulating the immune response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freeman, G J -- Borriello, F -- Hodes, R J -- Reiser, H -- Hathcock, K S -- Laszlo, G -- McKnight, A J -- Kim, J -- Du, L -- Lombard, D B -- CA 40216/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1993 Nov 5;262(5135):907-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7694362" target="_blank"〉PubMed〈/a〉
    Keywords: Abatacept ; Animals ; Antigens, CD ; Antigens, CD80/genetics/*immunology/metabolism ; Antigens, Differentiation/immunology/*metabolism ; B-Lymphocytes/*immunology ; Base Sequence ; CTLA-4 Antigen ; Cell Line ; *Immunoconjugates ; Interleukin-2/secretion ; Isoantigens/immunology ; Lymphocyte Activation ; Lymphocyte Culture Test, Mixed ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Sequence Data ; Mutation ; T-Lymphocytes/*immunology ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Ageing: Sorting out the sirtuins (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-03-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lombard, David B -- Miller, Richard A -- R01 GM101171/GM/NIGMS NIH HHS/ -- England -- Nature. 2012 Mar 7;483(7388):166-7. doi: 10.1038/nature10950.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22367538" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Longevity/*physiology ; Male ; *Sex Characteristics ; Sirtuins/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    Ageing: longevity hits a roadblock (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-09-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lombard, David B -- Pletcher, Scott D -- Canto, Carles -- Auwerx, Johan -- R01 GM101171/GM/NIGMS NIH HHS/ -- England -- Nature. 2011 Sep 21;477(7365):410-1. doi: 10.1038/477410a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology and Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48109, USA. davidlom@umich.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21938058" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caenorhabditis elegans/*physiology ; Caenorhabditis elegans Proteins/*genetics ; Drosophila Proteins/*genetics ; Drosophila melanogaster/*physiology ; Female ; Histone Deacetylases/*genetics ; Longevity/*physiology ; Male ; Sirtuins/*genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    Transmission of innate immune signaling by packaging of cGAMP in viral particles (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-08-01
    Description: Infected cells detect viruses through a variety of receptors that initiate cell-intrinsic innate defense responses. Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS) is a cytosolic sensor for many DNA viruses and HIV-1. In response to cytosolic viral DNA, cGAS synthesizes the second messenger 2'3'-cyclic GMP-AMP (cGAMP), which activates antiviral signaling pathways. We show that in cells producing virus, cGAS-synthesized cGAMP can be packaged in viral particles and extracellular vesicles. Viral particles efficiently delivered cGAMP to target cells. cGAMP transfer by viral particles to dendritic cells activated innate immunity and antiviral defenses. Finally, we show that cell-free murine cytomegalovirus and Modified Vaccinia Ankara virus contained cGAMP. Thus, transfer of cGAMP by viruses may represent a defense mechanism to propagate immune responses to uninfected target cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gentili, Matteo -- Kowal, Joanna -- Tkach, Mercedes -- Satoh, Takeshi -- Lahaye, Xavier -- Conrad, Cecile -- Boyron, Marilyn -- Lombard, Berangere -- Durand, Sylvere -- Kroemer, Guido -- Loew, Damarys -- Dalod, Marc -- Thery, Clotilde -- Manel, Nicolas -- New York, N.Y. -- Science. 2015 Sep 11;349(6253):1232-6. doi: 10.1126/science.aab3628. Epub 2015 Jul 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉INSERM U932, Immunity and Cancer Unit, Institut Curie, Paris, France. ; Centre d'Immunologie de Marseille-Luminy, Aix Marseille Universite UM2, INSERM U1104, CNRS UMR7280, 13288 Marseille, France. ; Laboratoire de Spectrometrie de Masse Proteomique, Institut Curie, Paris, France. ; Labex Dendritic Cell Biology (DCBIOL), Paris, France. ; Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, 94805 Villejuif, France. ; INSERM U932, Immunity and Cancer Unit, Institut Curie, Paris, France. Labex Dendritic Cell Biology (DCBIOL), Paris, France. ; INSERM U932, Immunity and Cancer Unit, Institut Curie, Paris, France. Labex Dendritic Cell Biology (DCBIOL), Paris, France. Labex Vaccine Research Institute (VRI), Paris, France. nicolas.manel@curie.fr.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26229115" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cercopithecus aethiops ; Cytosol/immunology/metabolism/virology ; Dendritic Cells/*immunology/virology ; Genetic Vectors/genetics/metabolism ; HIV Infections/immunology ; HIV-1/genetics/metabolism ; HeLa Cells ; Herpesviridae Infections/*immunology ; Humans ; Immunity, Innate/genetics/*immunology ; Mice ; Mice, Inbred C57BL ; Muromegalovirus/genetics/*metabolism ; Nucleotides, Cyclic/*metabolism ; *Second Messenger Systems ; Vaccinia/*immunology ; Vaccinia virus/genetics/*metabolism ; Vero Cells ; Virion/genetics/*metabolism ; Virus Assembly
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Ceriporiopsis genome [Microbiology] (2012)
    Fernandez–Fueyo, E., Ruiz–Duenas, F. J., Ferreira, P., Floudas, D., Hibbett, D. S., Canessa, P., Larrondo, L. F., James, T. Y., Seelenfreund, D., Lobos, S., Polanco, R., Tello, M., Honda, Y., Watanabe, T., , San, R. J., Kubicek, C. P., Schmoll, M., Gaskell, J., Hammel, K. E., St. John, F. J., Vanden Wymelenberg, A., Sabat, G., Splinter Bon; Durant, S., Syed, K., Yadav, J. S., Doddapaneni, H., Subramanian, V., Lavin, J. L., Oguiza, J. A., Perez, G., Pisabarro, A. G., Ramirez, L., Santoyo, F., Master, E., Coutinho, P. M., Henrissat, B., Lombard, V., Magnuson, J. K., Kues, U., Hori, C., Igarashi, K., Same&jnodot;ima, M., Held, B. W., Barry, K. W., La; Butti, K. M., Lapidus, A., Lindquist, E. A., Lucas, S. M., Riley, R., Salamov, A. A., Hoffmeister, D., Schwenk, D., Hadar, Y., Yarden, O., de Vries, R. P., Wiebenga, A., Stenlid, J., Eastwood, D., Grigoriev, I. V., Berka, R. M., Blanchette, R. A., Kersten, P., Martinez, A. T., Vicuna, R., Cullen, D.
    National Academy of Sciences
    Details
    Publication Date: 2012-04-04
    Description: Efficient lignin depolymerization is unique to the wood decay basidiomycetes, collectively referred to as white rot fungi. Phanerochaete chrysosporium simultaneously degrades lignin and cellulose, whereas the closely related species, Ceriporiopsis subvermispora, also depolymerizes lignin but may do so with relatively little cellulose degradation. To investigate the basis for selective ligninolysis, we conducted comparative genome analysis of C. subvermispora and P. chrysosporium. Genes encoding manganese peroxidase numbered 13 and five in C. subvermispora and P. chrysosporium, respectively. In addition, the C. subvermispora genome contains at least seven genes predicted to encode laccases, whereas the P. chrysosporium genome contains none. We also observed expansion of the number of C. subvermispora desaturase-encoding genes putatively involved in lipid metabolism. Microarray-based transcriptome analysis showed substantial up-regulation of several desaturase and MnP genes in wood-containing medium. MS identified MnP proteins in C. subvermispora culture filtrates, but none in P. chrysosporium cultures. These results support the importance of MnP and a lignin degradation mechanism whereby cleavage of the dominant nonphenolic structures is mediated by lipid peroxidation products. Two C. subvermispora genes were predicted to encode peroxidases structurally similar to P. chrysosporium lignin peroxidase and, following heterologous expression in Escherichia coli, the enzymes were shown to oxidize high redox potential substrates, but not Mn2+. Apart from oxidative lignin degradation, we also examined cellulolytic and hemicellulolytic systems in both fungi. In summary, the C. subvermispora genetic inventory and expression patterns exhibit increased oxidoreductase potential and diminished cellulolytic capability relative to P. chrysosporium.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 7
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    Highly accurate stability-preserving optimization of the Zener viscoelastic model, with application to wave propagation in the presence of strong attenuation (2016)
    Oxford University Press
    Details
    Publication Date: 2016-02-26
    Description: This paper concerns the numerical modelling of time-domain mechanical waves in viscoelastic media based on a generalized Zener model. To do so, classically in the literature relaxation mechanisms are introduced, resulting in a set of the so-called memory variables and thus in large computational arrays that need to be stored. A challenge is thus to accurately mimic a given attenuation law using a minimal set of relaxation mechanisms. For this purpose, we replace the classical linear approach of Emmerich & Korn with a nonlinear optimization approach with constraints of positivity. We show that this technique is more accurate than the linear approach. Moreover, it ensures that physically meaningful relaxation times that always honour the constraint of decay of total energy with time are obtained. As a result, these relaxation times can always be used in a stable way in a modelling algorithm, even in the case of very strong attenuation for which the classical linear approach may provide some negative and thus unusable coefficients.
    Keywords: Seismology
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 8
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    Wave propagation in a fractional viscoelastic Andrade medium: Diffusive approximation and numerical modeling (2014)
    Elsevier
    Details
    Publication Date: 2014-09-01
    Print ISSN: 0165-2125
    Electronic ISSN: 1878-433X
    Topics: Geosciences , Physics
    Published by Elsevier
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  • 9
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    Semi-analytical and numerical methods for computing transient waves in 2D acoustic/poroelastic stratified media (2012)
    Elsevier
    Details
    Publication Date: 2012-11-01
    Print ISSN: 0165-2125
    Electronic ISSN: 1878-433X
    Topics: Geosciences , Physics
    Published by Elsevier
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  • 10
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    Quantitation of phosphatidyl N-methyl- and N,N-Dimethylaminoethanol in rat liver (1976)
    Springer
    Details
    Publication Date: 1976-07-01
    Print ISSN: 0024-4201
    Electronic ISSN: 1558-9307
    Topics: Biology , Chemistry and Pharmacology
    Published by Springer
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