Publication Date:
2017-05-04
Description:
New complexes [(η 6 - p -cymene)Ru(C 5 H 4 N-2-CH=N–Ar) X ]PF 6 [ X = Br ( 1 ), I ( 2 ); Ar = 4-fluorophenyl ( a ), 4-chlorophenyl ( b ), 4-bromophenyl ( c ), 4-iodophenyl ( d ), 2,5-dichlorophenyl ( e )] were prepared, as well as 3a – 3e ( X = Cl) and the new complexes [(η 6 -arene)RuCl(N-N)]PF 6 (arene = C 6 H 5 OCH 2 CH 2 OH, N-N = 2,2′-bipyridine ( 4 ), 2,6-(dimethylphenyl)-pyridin-2-yl-methylene amine ( 5 ), 2,6-(diisopropylphenyl)-pyridin-2-yl-methylene amine ( 6 ); arene = p -cymene, N-N = 4-(aminophenyl)-pyridin-2-yl-methylene amine ( 7 )]. X-ray diffraction studies were performed for 1a , 1b , 1c , 1d , 2b , 5 , and 7 . Cytotoxicities of 1a – 1d and 2 were established versus human cancer cells epithelial colorectal adenocarcinoma (Caco-2) (IC 50 : 35.8–631.0 μM), breast adenocarcinoma (MCF7) (IC 50 : 36.3–128.8.0 μM), and hepatocellular carcinoma (HepG2) (IC 50 : 60.6–439.8 μM), 3a – 3e were tested against HepG2 and Caco-2, and 4 – 7 were tested against Caco-2. 1 – 7 were tested against non-cancerous human epithelial kidney cells. 1 and 2 were more selective towards tumor cells than the anticancer drug 5-fluorouracil (5-FU), but 3a – 3e ( X = Cl) were not selective. 1 and 2 had good activity against MCF7, some with lower IC 50 than 5-FU. Complexes with X = Br or I had moderate activity against Caco-2 and HepG2, but those with Cl were inactive. Antibacterial activities of 1a , 2b , 3a , and 7 were tested against antibacterial susceptible and resistant Gram-negative and -positive bacteria. 1a , 2b , and 3a showed activity against methicillin-resistant S. aureus (MIC = 31–2000 μg · mL –1 ).
Print ISSN:
0044-2313
Electronic ISSN:
1521-3749
Topics:
Chemistry and Pharmacology
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