Publication Date:
2015-04-09
Description:
The family Filoviridae contains three genera, Ebolavirus (EBOV), Marburg virus, and Cuevavirus. Some members of the EBOV genus, including Zaire ebolavirus (ZEBOV), can cause lethal haemorrhagic fever in humans. During 2014 an unprecedented ZEBOV outbreak occurred in West Africa and is still ongoing, resulting in over 10,000 deaths, and causing global concern of uncontrolled disease. To meet this challenge a rapid-acting vaccine is needed. Many vaccine approaches have shown promise in being able to protect nonhuman primates against ZEBOV. In response to the current ZEBOV outbreak several of these vaccines have been fast tracked for human use. However, it is not known whether any of these vaccines can provide protection against the new outbreak Makona strain of ZEBOV. One of these approaches is a first-generation recombinant vesicular stomatitis virus (rVSV)-based vaccine expressing the ZEBOV glycoprotein (GP) (rVSV/ZEBOV). To address safety concerns associated with this vector, we developed two candidate, further-attenuated rVSV/ZEBOV vaccines. Both attenuated vaccines produced an approximately tenfold lower vaccine-associated viraemia compared to the first-generation vaccine and both provided complete, single-dose protection of macaques from lethal challenge with the Makona outbreak strain of ZEBOV.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629916/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629916/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mire, Chad E -- Matassov, Demetrius -- Geisbert, Joan B -- Latham, Theresa E -- Agans, Krystle N -- Xu, Rong -- Ota-Setlik, Ayuko -- Egan, Michael A -- Fenton, Karla A -- Clarke, David K -- Eldridge, John H -- Geisbert, Thomas W -- R01 AI098817/AI/NIAID NIH HHS/ -- R01AI09881701/AI/NIAID NIH HHS/ -- U19 AI109711/AI/NIAID NIH HHS/ -- England -- Nature. 2015 Apr 30;520(7549):688-91. doi: 10.1038/nature14428. Epub 2015 Apr 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Galveston National Laboratory, University of Texas Medical Branch, Galveston, Texas 77550, USA [2] Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77550, USA. ; Department of Virology and Vaccine Vectors, Profectus BioSciences, Inc., Tarrytown, New York 10591, USA. ; Department of Immunology, Profectus BioSciences, Inc., Tarrytown, New York 10591, USA. ; 1] Department of Virology and Vaccine Vectors, Profectus BioSciences, Inc., Tarrytown, New York 10591, USA [2] Department of Immunology, Profectus BioSciences, Inc., Tarrytown, New York 10591, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25853476" target="_blank"〉PubMed〈/a〉
Keywords:
Africa, Western/epidemiology
;
Animals
;
Antibodies, Viral/immunology
;
Democratic Republic of the Congo/epidemiology
;
Ebola Vaccines/*administration & dosage/genetics/*immunology
;
Ebolavirus/classification/*immunology
;
Female
;
Genetic Vectors/genetics
;
Hemorrhagic Fever, Ebola/immunology/*prevention & control/*virology
;
Humans
;
Immunoglobulin G/immunology
;
Kinetics
;
Macaca fascicularis
;
Male
;
Survival Analysis
;
Vaccination
;
Vaccines, Attenuated/administration & dosage/genetics/*immunology
;
Vesiculovirus/*genetics/growth & development
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
