Publication Date:
2010-04-23
Description:
A key question in developmental biology is how cells exchange positional information for proper patterning during organ development. In plant roots the radial tissue organization is highly conserved with a central vascular cylinder in which two water conducting cell types, protoxylem and metaxylem, are patterned centripetally. We show that this patterning occurs through crosstalk between the vascular cylinder and the surrounding endodermis mediated by cell-to-cell movement of a transcription factor in one direction and microRNAs in the other. SHORT ROOT, produced in the vascular cylinder, moves into the endodermis to activate SCARECROW. Together these transcription factors activate MIR165a and MIR166b. Endodermally produced microRNA165/6 then acts to degrade its target mRNAs encoding class III homeodomain-leucine zipper transcription factors in the endodermis and stele periphery. The resulting differential distribution of target mRNA in the vascular cylinder determines xylem cell types in a dosage-dependent manner.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967782/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967782/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carlsbecker, Annelie -- Lee, Ji-Young -- Roberts, Christina J -- Dettmer, Jan -- Lehesranta, Satu -- Zhou, Jing -- Lindgren, Ove -- Moreno-Risueno, Miguel A -- Vaten, Anne -- Thitamadee, Siripong -- Campilho, Ana -- Sebastian, Jose -- Bowman, John L -- Helariutta, Yka -- Benfey, Philip N -- R01 GM043778/GM/NIGMS NIH HHS/ -- R01 GM043778-17/GM/NIGMS NIH HHS/ -- R01 GM043778-18/GM/NIGMS NIH HHS/ -- R01 GM043778-19/GM/NIGMS NIH HHS/ -- R01 GM043778-20/GM/NIGMS NIH HHS/ -- R01 GM043778-21/GM/NIGMS NIH HHS/ -- R01-GM043778/GM/NIGMS NIH HHS/ -- England -- Nature. 2010 May 20;465(7296):316-21. doi: 10.1038/nature08977. Epub 2010 Apr 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Biotechnology/Department of Biosciences, University of Helsinki, FIN-00014, Finland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20410882" target="_blank"〉PubMed〈/a〉
Keywords:
Arabidopsis/cytology/genetics/growth & development/*metabolism
;
Arabidopsis Proteins/metabolism
;
Body Patterning
;
*Cell Lineage
;
Cell Movement
;
Endoderm/cytology/metabolism
;
*Gene Dosage
;
Gene Expression Regulation, Plant
;
MicroRNAs/genetics/*metabolism
;
Organogenesis
;
Plant Roots/*cytology/genetics/growth & development/metabolism
;
RNA Transport
;
RNA, Plant/genetics/*metabolism
;
*Signal Transduction
;
Transcription Factors/metabolism
;
Xylem/cytology/growth & development/metabolism
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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