Publication Date:
2002-05-04
Description:
Animal cells exert exquisite control over the physical and chemical properties of their membranes, but the mechanisms are obscure. We show that phosphatidylethanolamine, the major phospholipid in Drosophila, controls the release of sterol regulatory element-binding protein (SREBP) from Drosophila cell membranes, exerting feedback control on the synthesis of fatty acids and phospholipids. The finding that SREBP processing is controlled by different lipids in mammals and flies (sterols and phosphatidylethanolamine, respectively) suggests that an essential function of SREBP is to monitor cell membrane composition and to adjust lipid synthesis accordingly.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dobrosotskaya, I Y -- Seegmiller, A C -- Brown, M S -- Goldstein, J L -- Rawson, R B -- GM 08014/GM/NIGMS NIH HHS/ -- HL-20948/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2002 May 3;296(5569):879-83.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9046, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11988566" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
CCAAT-Enhancer-Binding Proteins/genetics/*metabolism
;
Cell Membrane/metabolism
;
Cell Nucleus/metabolism
;
Ceramides/metabolism/pharmacology
;
Cholesterol/metabolism
;
DNA-Binding Proteins/genetics/*metabolism
;
Drosophila/genetics/*metabolism
;
Drosophila Proteins/genetics/metabolism
;
Enzyme Inhibitors/pharmacology
;
Fatty Acids/biosynthesis
;
Fatty Acids, Monounsaturated/pharmacology
;
Feedback, Physiological
;
Gene Silencing
;
Intracellular Signaling Peptides and Proteins
;
Membrane Lipids/*biosynthesis
;
Membrane Proteins/metabolism
;
Palmitates/*metabolism/pharmacology
;
Phosphatidylcholines/biosynthesis
;
Phosphatidylethanolamines/biosynthesis/*metabolism
;
Phospholipids/biosynthesis
;
RNA, Messenger/genetics/metabolism
;
RNA, Small Interfering
;
RNA, Untranslated/pharmacology
;
Sterol Regulatory Element Binding Protein 1
;
Transcription Factors/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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