ISSN:
1434-193X
Keywords:
Oligonucleotides
;
Conjugation
;
Porphyrinoids
;
Solid-phase synthesis
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
---A convenient solid-phase synthesis of oligonucleotides conjugated at the 3′-end with a tetraphenylporphyrin residue, by means of a new polymeric support bearing as a linker a lysine derivative, has been developed. A porphyrin linked 17-mer, designed for antisense experiments, has been prepared in good yields, and its hybridization properties with a complementary DNA fragment evaluated by UV thermal analysis.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
Permalink