Publication Date:
1996-06-07
Description:
Certain chemicals in the environment are estrogenic. The low potencies of these compounds, when studied singly, suggest that they may have little effect on biological systems. The estrogenic potencies of combinations of such chemicals were screened in a simple yeast estrogen system (YES) containing human estrogen receptor (hER). Combinations of two weak environmental estrogens, such as dieldrin, endosulfan, or toxaphene, were 1000 times as potent in hER-mediated transactivation as any chemical alone. Hydroxylated polychlorinated biphenyls shown previously to synergistically alter sexual development in turtles also synergized in the YES. The synergistic interaction of chemical mixtures with the estrogen receptor may have profound environmental implications. These results may represent a previously uncharacterized level of regulation of estrogen-associated responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arnold, S F -- Klotz, D M -- Collins, B M -- Vonier, P M -- Guillette, L J Jr -- McLachlan, J A -- New York, N.Y. -- Science. 1996 Jun 7;272(5267):1489-92.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Environmental Health Sciences, Tulane University of Public Health and Tropical Medicine, New Orleans, LA 70112, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8633243" target="_blank"〉PubMed〈/a〉
Keywords:
Binding, Competitive
;
Chlordan/metabolism/pharmacology
;
Dieldrin/metabolism/pharmacology
;
Drug Synergism
;
Endosulfan/metabolism/pharmacology
;
Environmental Pollutants/metabolism/*pharmacology
;
Estradiol/metabolism
;
Estrogens, Non-Steroidal/metabolism/*pharmacology
;
Genes, Reporter
;
Humans
;
Insecticides/metabolism/*pharmacology
;
Polychlorinated Biphenyls/*pharmacology
;
Receptors, Estrogen/*drug effects/metabolism
;
Saccharomyces cerevisiae/drug effects/genetics
;
Toxaphene/metabolism/pharmacology
;
Tumor Cells, Cultured
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink