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  • 1
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    Why the smallpox virus stocks should not be destroyed (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1993-11-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Joklik, W K -- Moss, B -- Fields, B N -- Bishop, D H -- Sandakhchiev, L S -- New York, N.Y. -- Science. 1993 Nov 19;262(5137):1225-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Duke University Medical Center, Durham, NC 27710.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8235652" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Biological Specimen Banks ; Centers for Disease Control and Prevention (U.S.) ; *Containment of Biohazards ; Genome, Viral ; Humans ; Preservation, Biological ; Smallpox/*prevention & control ; United States ; *Variola virus/genetics ; World Health Organization
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    Intestinal M cells: a pathway for entry of reovirus into the host (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-04-24
    Beschreibung: Thirty minutes after inoculation of reovirus type 1 into the intestinal lumen of the mouse, viruses were found adhering to the surface of intestinal M cells but not other epithelial cells. Within 1 hour, viruses were seen in the M cell cytoplasm and were associated with mononuclear cells in the intercellular space adjacent to the M cell. These findings suggest that M cells are the site where reovirus penetrates the intestinal epithelium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolf, J L -- Rubin, D H -- Finberg, R -- Kauffman, R S -- Sharpe, A H -- Trier, J S -- Fields, B N -- AI 13178/AI/NIAID NIH HHS/ -- AM 07121/AM/NIADDK NIH HHS/ -- AM 17537/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1981 Apr 24;212(4493):471-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6259737" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Animals, Suckling/microbiology ; Endocytosis ; Extracellular Space/microbiology ; Intestinal Mucosa/cytology/*microbiology ; Mice ; Peyer's Patches/microbiology ; Receptors, Virus/metabolism ; Reoviridae/*physiology ; Reoviridae Infections/*pathology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    Hemagglutinin variants of reovirus type 3 have altered central nervous system tropism (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-29
    Beschreibung: Variants of the Dearing strain of reovirus type 3 with antigenically altered hemagglutinin proteins are much less neurovirulent than the parental virus. When injected intracerebrally into mice these variants infected a subset of the brain neurons that were infected by the parental virus. When injected intraperitoneally, the variants did not spread to the brain. These results indicate that minor modifications of the reovirus hemagglutinin dramatically alter the ability of the virus to spread into and injure the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spriggs, D R -- Bronson, R T -- Fields, B N -- NS-16998-01/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):505-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301010" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Monoclonal/immunology ; Brain/pathology ; Brain Diseases/*microbiology/pathology ; Hemagglutination Tests ; Mammalian orthoreovirus 3/immunology/*pathogenicity ; Mice ; Reoviridae/*pathogenicity ; Reoviridae Infections/microbiology/pathology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    Ammonium chloride prevents lytic growth of reovirus and helps to establish persistent infection in mouse L cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-02-25
    Beschreibung: Ammonium chloride, a lysosomotropic agent that raises intralysosomal pH, reduces the yield of reovirus during infection of mouse L cells. Subsequent removal of ammonium chloride results in the rapid establishment of a persistent infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Canning, W M -- Fields, B N -- AI 13178/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1983 Feb 25;219(4587):987-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6297010" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Ammonium Chloride/*pharmacology ; Animals ; Hydrogen-Ion Concentration ; L Cells (Cell Line) ; Lysosomes/physiology ; Mice ; Reoviridae/*growth & development ; Reoviridae Infections/*etiology ; Virus Replication/*drug effects
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
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    Distinct pathways of viral spread in the host determined by reovirus S1 gene segment (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1986-08-15
    Beschreibung: The genetic and molecular mechanisms that determine the capacity of a virus to utilize distinct pathways of spread in an infected host were examined by using reoviruses. Both reovirus type 1 and reovirus type 3 spread to the spinal cord following inoculation into the hindlimb or forelimb footpad of newborn mice. For type 3 this spread is through nerves and occurs via the microtubule-associated system of fast axonal transport. By contrast, type 1 spreads to the spinal cord through the bloodstream. With the use of reassortant viruses containing various combinations of double-stranded RNA segments (genes) derived from type 1 and type 3, the viral S1 double-stranded RNA segment was shown to be responsible for determining the capacity of reoviruses to spread to the central nervous system through these distinct pathways.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tyler, K L -- McPhee, D A -- Fields, B N -- 2 P01 NS16998/NS/NINDS NIH HHS/ -- 5 R01 AI13178/AI/NIAID NIH HHS/ -- K11-AI00610/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1986 Aug 15;233(4765):770-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3016895" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Forelimb ; *Genes, Viral ; Hindlimb ; Mammalian orthoreovirus 3/*genetics/pathogenicity ; Mice ; Reoviridae/*genetics/pathogenicity ; Reoviridae Infections/microbiology ; Sciatic Nerve/physiology ; Species Specificity ; Spinal Cord/*microbiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
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    Visualization of viral clearance in the living animal (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1987-04-24
    Beschreibung: The early events in viral dissemination via the bloodstream were identified by monitoring the fate of 123I-radiolabeled reovirus after it was injected intravenously in rats. Continuous scintillation camera imaging showed that reovirus serotypes 1 and 3 were cleared from the circulation in less than 10 minutes by specific and distinct target organs. Reovirus serotype 1 accumulated predominantly in the lungs and the liver, whereas serotype 3 accumulated in the liver and the spleen with very little virus uptake by the lungs. Incubation of reovirus serotype 1 with a monoclonal antibody directed against the viral hemagglutinin before injection totally inhibited the clearance of the virus by the lungs. Similar results were obtained when viruses biolabeled with 35S were used. These results demonstrate that viruses can be rapidly transported through the bloodstream to specific target organs and that the localization of the viruses depends on the interaction between specific viral surface components and the target organ.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Verdin, E M -- Maratos-Flier, E -- Kahn, C R -- Sodoyez, J C -- Sodoyez-Goffaux, F -- De Vos, C J -- Lynn, S P -- Fields, B N -- AI 3178/AI/NIAID NIH HHS/ -- AM 01252/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1987 Apr 24;236(4800):439-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3031817" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antigen-Antibody Complex ; Iodine Radioisotopes ; Mammalian orthoreovirus 3/physiology ; Reoviridae/immunology/*physiology ; Reoviridae Infections/*microbiology ; Time Factors ; Tissue Distribution
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
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    Viral shedding and transmission between hosts determined by reovirus L2 gene (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1986-06-27
    Beschreibung: Two reovirus isolates (type 1 Lang and type 3 Dearing) differ in their transmissibility between littermates of newborn mice. They also differ in the amounts of virus excreted by the gastrointestinal tract. With the use of reassortant viruses, these properties were mapped to the L2 gene. Thus environmental spread of reovirus is a genetic property.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keroack, M -- Fields, B N -- 5R01 AI13178/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1986 Jun 27;232(4758):1635-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3012780" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Animals, Newborn/microbiology ; Digestive System/microbiology ; *Genes, Viral ; Mammalian orthoreovirus 3/physiology ; Mice ; Reoviridae/physiology ; Reoviridae Infections/microbiology/*transmission
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
    Digitale Medien
    Digitale Medien
    Genetics of reovirus virulence
    Amsterdam : Elsevier
    Trends in Genetics 1 (1985), S. 284-287 
    Details
    ISSN: 0168-9525
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0168-9525(85)90106-4
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  • 9
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    Ion channels induced in lipid bilayers by subvirion particles of the nonenveloped mammalian reoviruses. (1993)
    National Academy of Sciences
    Details
    Publikationsdatum: 1993-11-15
    Print ISSN: 0027-8424
    Digitale ISSN: 1091-6490
    Thema: Biologie , Medizin , Allgemeine Naturwissenschaft
    Publiziert von National Academy of Sciences
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  • 10
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    Direct spread of reovirus from the intestinal lumen to the central nervous system through vagal autonomic nerve fibers. (1991)
    National Academy of Sciences
    Details
    Publikationsdatum: 1991-05-01
    Print ISSN: 0027-8424
    Digitale ISSN: 1091-6490
    Thema: Biologie , Medizin , Allgemeine Naturwissenschaft
    Publiziert von National Academy of Sciences
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