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  • Articles  (43)
  • Biology  (43)
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  • Articles  (43)
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  • 1
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    Affective neurons in human subthalamus [Neuroscience] (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-03-11
    Description: Both animal studies and studies using deep brain stimulation in humans have demonstrated the involvement of the subthalamic nucleus (STN) in motivational and emotional processes; however, participation of this nucleus in processing human emotion has not been investigated directly at the single-neuron level. We analyzed the relationship between the neuronal...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-05-28
    Description: Selective autophagy can be mediated via receptor molecules that link specific cargoes to the autophagosomal membranes decorated by ubiquitin-like microtubule-associated protein light chain 3 (LC3) modifiers. Although several autophagy receptors have been identified, little is known about mechanisms controlling their functions in vivo. In this work, we found that phosphorylation of an autophagy receptor, optineurin, promoted selective autophagy of ubiquitin-coated cytosolic Salmonella enterica. The protein kinase TANK binding kinase 1 (TBK1) phosphorylated optineurin on serine-177, enhancing LC3 binding affinity and autophagic clearance of cytosolic Salmonella. Conversely, ubiquitin- or LC3-binding optineurin mutants and silencing of optineurin or TBK1 impaired Salmonella autophagy, resulting in increased intracellular bacterial proliferation. We propose that phosphorylation of autophagy receptors might be a general mechanism for regulation of cargo-selective autophagy.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714538/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714538/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wild, Philipp -- Farhan, Hesso -- McEwan, David G -- Wagner, Sebastian -- Rogov, Vladimir V -- Brady, Nathan R -- Richter, Benjamin -- Korac, Jelena -- Waidmann, Oliver -- Choudhary, Chunaram -- Dotsch, Volker -- Bumann, Dirk -- Dikic, Ivan -- 250241/European Research Council/International -- New York, N.Y. -- Science. 2011 Jul 8;333(6039):228-33. doi: 10.1126/science.1205405. Epub 2011 May 26.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Frankfurt Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University School of Medicine, Frankfurt (Main), Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21617041" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing/metabolism ; *Autophagy ; Cell Line, Tumor ; Cytosol/*microbiology ; HeLa Cells ; Humans ; Immunity, Innate ; Microtubule-Associated Proteins/metabolism ; Models, Biological ; Nuclear Proteins/chemistry/metabolism ; Phosphorylation ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein-Serine-Threonine Kinases/metabolism ; RNA Interference ; Salmonella typhimurium/*growth & development/immunology ; Transcription Factor TFIIIA/chemistry/genetics/*metabolism ; Ubiquitin/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Silicone rubber substrata: a new wrinkle in the study of cell locomotion (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-11
    Description: When tissue cells are cultured on very thin sheets of cross-linked silicone fluid, the traction forces the cells exert are made visible as elastic distortion and wrinkling of this substratum. Around explants this pattern of wrinkling closely resembles the "center effects" long observed in plasma clots and traditionally attributed to dehydration shrinkage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harris, A K -- Wild, P -- Stopak, D -- New York, N.Y. -- Science. 1980 Apr 11;208(4440):177-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6987736" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Movement ; Cells, Cultured/physiology ; Chick Embryo ; Microscopy, Interference ; Microscopy, Phase-Contrast ; *Silicone Elastomers
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
    Electronic Resource
    Electronic Resource
    Measurement of Magnetic Fields in Interstellar Clouds (1962)
    [s.l.] : Nature Publishing Group
    Nature 196 (1962), S. 563-563 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] These observations were made in September and October, 1962, with the 250-ft. telescope using a parametric amplifier (AIL Type 1930) and a radio frequency switch incorporating varactor diodes as switching elements which gave an overall system noise temperature of about 200 K. Crystal filters having ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/196563a0
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    A New Limit to the Galactic Magnetic Field Set by Measurements of the Zeeman Splitting of the Hydrogen Line (1960)
    [s.l.] : Nature Publishing Group
    Nature 187 (1960), S. 1088-1089 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE existence of a magnetic field in the Milky JL Way system has been inferred from the regularity in direction of polarization of the light from distant stars, from the isotropy of high-energy cosmic rays and the presence of galactic radio-frequency emission attributed to the synchrotron ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1871088a0
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of estradiol on parathyroid cell activity (1989)
    Springer
    Cellular and molecular life sciences 45 (1989), S. 1121-1123 
    Details
    ISSN: 1420-9071
    Keywords: Estradiol ; parathyroid ; exocytosis ; membrane synthesis ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Beta-estradiol-3-benzoate provoked an initial centrifugal membrane shift in rat parathyroid cells and, later, enlargement of the compartments concerned with parathyroid hormone secretion, which suggests that estradiol modulates not only transport and release of parathyroid hormone but also the capacity for its synthesis, packaging and storage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01950176
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  • 7
    Electronic Resource
    Electronic Resource
    Restriction site maps of a new type of bovine herpesvirus 1 (1986)
    Springer
    Cellular and molecular life sciences 42 (1986), S. 93-93 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01975934
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  • 8
    Electronic Resource
    Electronic Resource
    New phases in the system Zn−In−S (1969)
    Springer
    Naturwissenschaften 56 (1969), S. 86-86 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00590572
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  • 9
    Electronic Resource
    Electronic Resource
    The effect of o,p′-DDD on the adrenal cortex in sheep (1982)
    Springer
    Cellular and molecular life sciences 38 (1982), S. 1494-1496 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effect of o,p′-DDD (200 mg/kg/day given p.o. for 100 consecutive days) on the sheep adrenal gland was studied. The results suggest that this ruminant species is highly resistant to the adrenocorticolytic activity of o,p′-DDD when compared with dogs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955790
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  • 10
    Electronic Resource
    Electronic Resource
    Parathyroid cell variants may be provoked during immersion fixation (1987)
    Springer
    Histochemistry and cell biology 87 (1987), S. 263-271 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Parathyroid glands of cattle, dogs, cats, mice and rats were immersed in glutaraldehyde or mixtures consisting of glutaraldehyde, formaldehyde and acrolein in either Na-phosphate, Na/K-phosphate or Na-cacodylate buffer, and postfixed with OsO4 in the same buffers or, alternatively, in s-collidine. Excellent preservation of bovine, feline and murine parathyroid glands was achieved with fixation mixtures containing 1% glutaraldehyde, 1.5–2% formaldehyde and 2.5–5% acrolein in 0.1 M Na-cacodylate with or without Ca2+ and Mg2+, Na-phosphate or Na/K-phosphate at 4°C followed by postfixation with 1% OsO4 in the same buffers or in s-collidine containing sucrose, Ca2+ and Mg2+. This procedure largely abolished the occurence of parathyroid cell variants. Bovine parathyroid glands were also satisfactorily preserved with 1% glutaraldehyde and 2% formaldehyde whereas 1% glutaraldehyde and 2.5 or 5% acrolein, lower or higher buffer osmolarity, or immersion at room temperature led to vacuolization of RER and to breakdown of membranes. In contrast, all fixation protocols led to the formation of dark and light cell variants and to multinucleated syncytial cells in dog and rat parathyroids. The results thus show that parathyroid cell variants arise during immersion fixation and that aldehydes, buffers and temperature are important factors for provoking parathyroid cell variants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00492420
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