Publication Date:
2017-04-07
Description:
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides Nature Communications, Published online: 6 April 2017; doi:10.1038/ncomms14773 JmjC histone demethylases (KDMs) are cancer targets due to their links to cell proliferation, but selective inhibition remains a challenge. Here the authors identify potent inhibitors of KDM4A-C—via in vitro selection from a vast library of cyclic peptides—that show selectivity over other KDMs.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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