Publication Date:
2000-09-01
Description:
We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of life-span and that it can be counteracted by pharmacological intervention.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Melov, S -- Ravenscroft, J -- Malik, S -- Gill, M S -- Walker, D W -- Clayton, P E -- Wallace, D C -- Malfroy, B -- Doctrow, S R -- Lithgow, G J -- AG-13154/AG/NIA NIH HHS/ -- NS21328/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2000 Sep 1;289(5484):1567-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Buck Institute for Age Research, Novato, CA 94949, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10968795" target="_blank"〉PubMed〈/a〉
Keywords:
Aging/*drug effects
;
Animals
;
Antioxidants/*pharmacology
;
Caenorhabditis elegans/drug effects/*physiology
;
Catalase/*metabolism
;
Disorders of Sex Development
;
Fertility/drug effects
;
Longevity/drug effects
;
Molecular Mimicry
;
Oxidative Stress
;
Reactive Oxygen Species/metabolism
;
Superoxide Dismutase/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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