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  • 1
    Electronic Resource
    Electronic Resource
    Effects of Transdermal Penetration Enhancers on the Permeability of Shed Snakeskin (1992)
    Springer
    Pharmaceutical research 9 (1992), S. 1168-1172 
    Details
    ISSN: 1573-904X
    Keywords: shed snakeskin ; Elaphe obsoleta ; transdermal ; penetration enhancer ; Azone ; lauryl alcohol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The effects of Azone and lauryl alcohol on the permeability of shed snakeskin were examined. Permeability of a variety of compounds through shed snakeskin was increased after Azone or lauryl alcohol pretreatment but the magnitude of the enhancement varied depending on the lipophilicity and the molecular size of the permeant. It was found that the shed snakeskin became more permeable after Azone or lauryl alcohol pretreatment, with a greater permeability increase for more hydrophilic and larger-molecular size permeants. As has been shown for untreated shed snakeskins, both the lipophilicity and the molecular size of the permeants are important in skin penetration and in determining the effects of transdermal penetration enhancers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015851805563
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  • 2
    Electronic Resource
    Electronic Resource
    Use of Shed Snake Skin as a Model Membrane for in Vitro Percutaneous Penetration Studies: Comparison with Human Skin (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 1042-1047 
    Details
    ISSN: 1573-904X
    Keywords: skin penetration ; transdermal ; shed snake skin ; functional group contribution ; Azone ; Elaphe obsoleta
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The potential usefulness of shed snake skin as a model membrane for transdermal research was examined. There are similarities between shed snake skin and human stratum corneum in terms of structure, composition, lipid content, water permeability, etc. The permeability of various compounds and the contribution of several functional groups to the permeability were also found to be similar between shed snake skin and human skin. Moreover, the permeability of compounds through shed snake skin was increased by Azone, one of the most extensively studied transdermal penetration enhancers. Considering the similarities between shed snake skin and human skin, ease of storage and handling, and low cost, shed snake skin may offer a good model membrane for transdermal research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015943200982
    Location Call Number Expected Availability
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    Paper (German National Licenses)
    Fulltext
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