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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Pharmaceutical research 10 (1993), S. 588-592 
    ISSN: 1573-904X
    Keywords: theophylline ; sustained release ; bioavailability ; deconvolution ; in vivo/in vitro correlation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A novel multiparticulate sustained-release theophylline formulation, which consisted of spherical drug pellets coated with a rate-controlling membrane, was evaluated in vivo. Two preparations that differ solely in the coat thickness, and hence rate of in vitro drug release, were studied in comparison with a solution of the drug. Both preparations produced serum concentration profiles that are reflective of a slow and sustained rate of absorption. The in vivo release versus time profiles calculated using a deconvolution procedure showed that the two preparations differed in the rate but not the extent of drug release. Satisfactory correlation was also obtained between the in vivo and the in vitro results. When the two preparations were further compared using the parameters, time to reach peak concentration (T p), peak concentration (C p), and total area under the serum concentration versus time curves (AUC), a statistically significant difference was observed in the T p and C p values but not the AUC values, suggesting that the preparations differed in the rate but not the extent of absorption. In addition, the extent of absorption from both preparations was comparable to that obtained with the drug solution.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Natural hazards 16 (1997), S. 219-241 
    ISSN: 1573-0840
    Keywords: hazard mitigation ; federal emergency legislation ; mitigation policy ; mitigation programs ; emergency management ; IDNDR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography , Geosciences
    Notes: Abstract Exposure to natural hazards tends to be poorly understood and yet implicitly accepted by a large proportion of populations at risk. Some people through years of experience and time-tested coping mechanisms effectively respond to most hazards. Others, lacking skills and experience, are dependent on institutional response systems for immediate assistance and long-term recovery. Clearly, both approaches can reduce losses; however, the former strategies often prove more cost effective. How then, can loss reduction be handled with minimal external involvement? Are there not strategies that can reduce the impact of natural hazards and minimize exposure to these risks? Introduction of hazard mitigation strategies can begin to address these concerns in a timely and cost effective manner. Federal institutions in Canada and the United States recognize this potential, and in response, have developed policies and designed programs to limit the impact of hazards. To further collective thinking on hazard mitigation, this paper surveys current legislation and programs in both countries, makes a comparative assessment, and seeks to identify implications for mitigation policy within the framework of the Canadian IDNDR initiative. Perceptions of mitigation are explored to create a common foundation from which to address the nature, direction, and structure of mitigation policy and programs in Canada. Clarity of purpose, awareness of context, and acknowledgment of limitations and conflicts represent crucial aspects in the evolution of mitigation strategies. Through awareness, understanding, and a willingness to engage in dialogue new ways of thinking can be employed to decrease the impact of natural hazards on society and the environment.
    Type of Medium: Electronic Resource
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