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  • 1
    Electronic Resource
    Electronic Resource
    Selective breeding for high and low levels of opiate-induced analgesia in mice (1983)
    Springer
    Behavior genetics 13 (1983), S. 383-396 
    Details
    ISSN: 1573-3297
    Keywords: mice ; selective breeding ; selection ; analgesia ; antinociception ; levorphanol ; morphine ; hot plate test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Beginning with a genetically heterogeneous outbred stock of mice (Binghamton HET), selective breeding was conducted within two selected lines for a high analgesic (antinociceptive) response and a low analgesic response, respectively, to a narcotic analgesic (levorphanol tartrate) using the hot-plate test. A nonselected control line was also maintained concurrently. Four generations of predominantly mass selection have produced a marked divergence between the two oppositely selected lines, yielding a realized heritability (h 2) of 0.32±0.05. The selection response was markedly asymmetrical, with a realizedh 2 in the high direction of 0.45±0.10 and in the low direction of 0.12±0.07. These animals represent potentially useful subject material for research concerning the mechanisms and correlates of opiate-induced analgesia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01065776
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  • 2
    Electronic Resource
    Electronic Resource
    Inbred strain differences in morphine-induced analgesia with the hot plate assay: A reassessment (1990)
    Springer
    Behavior genetics 20 (1990), S. 333-338 
    Details
    ISSN: 1573-3297
    Keywords: DBA/2J ; C57BL/6J ; C3H/HeJ ; morphine ; analgesia ; hot plate assay ; genetics ; opioid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Using the hot plate assay of analgesia, several investigators have reported DBA/2J mice to be much more sensitive to morphine and other opioids than C57BL/6J mice using paw-lick as the behavioral end point. In the present studies, we compared DBA/2J, C57BL/6J, and C3H/HeJ mice on two behavioral end points, either (1) the initial response to the hot plate, either a hind paw-lift, paw-shake, or paw-lick, whichever occurred first, or (2) the paw-lick response. In response to either morphine or saline, all three strains showed roughly equivalent latencies to the initial response, but the DBA/2J strain was markedly slow to show paw-lick as a nocifensive response compared to the C57BL/6J strain. As a result, only for the paw-lick response were there significant differences among the three inbred strains in morphine analgesia. Thus, differences in analgesic sensitivity among these strains are largely a function of the behavioral end point used to assess nociception to the hot plate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01067800
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