Publication Date:
2008-02-23
Description:
Natural vision is a highly dynamic process. Frequent body, head, and eye movements constantly bring new images onto the retina for brief periods, challenging our understanding of the neural code for vision. We report that certain retinal ganglion cells encode the spatial structure of a briefly presented image in the relative timing of their first spikes. This code is found to be largely invariant to stimulus contrast and robust to noisy fluctuations in response latencies. Mechanistically, the observed response characteristics result from different kinetics in two retinal pathways ("ON" and "OFF") that converge onto ganglion cells. This mechanism allows the retina to rapidly and reliably transmit new spatial information with the very first spikes emitted by a neural population.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gollisch, Tim -- Meister, Markus -- R01 EY014737/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 2008 Feb 22;319(5866):1108-11. doi: 10.1126/science.1149639.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18292344" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials
;
Ambystoma
;
Animals
;
Kinetics
;
Models, Neurological
;
Photic Stimulation
;
Reaction Time
;
Retinal Bipolar Cells/physiology
;
Retinal Ganglion Cells/*physiology
;
Saccades
;
Synapses/physiology
;
Vision, Ocular/*physiology
;
Visual Pathways/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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