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  • 1
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    Cheater-resistance is not futile (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-10-02
    Description: Cooperative social systems are susceptible to cheating by individuals that reap the benefits of cooperation without incurring the costs. There are various theoretical mechanisms for the repression of cheating and many have been tested experimentally. One possibility that has not been tested rigorously is the evolution of mutations that confer resistance to cheating. Here we show that the presence of a cheater in a population of randomly mutated social amoebae can select for cheater-resistance. Furthermore, we show that this cheater-resistance can be a noble strategy because the resister strain does not necessarily exploit other strains. Thus, the evolution of resisters may be instrumental in preserving cooperative behaviour in the face of cheating.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Khare, Anupama -- Santorelli, Lorenzo A -- Strassmann, Joan E -- Queller, David C -- Kuspa, Adam -- Shaulsky, Gad -- England -- Nature. 2009 Oct 15;461(7266):980-2. doi: 10.1038/nature08472. Epub 2009 Sep 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19794414" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cooperative Behavior ; Dictyostelium/genetics/*physiology ; Evolution, Molecular ; Genes, Protozoan/genetics ; *Models, Biological ; Mutation/genetics ; Protozoan Proteins/genetics/metabolism ; *Social Behavior ; Spores, Protozoan/physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Periodic signaling controlled by an oscillatory circuit that includes protein kinases ERK2 and PKA (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-05-08
    Description: Self-regulating systems often use robust oscillatory circuits. One such system controls the chemotactic signaling mechanism of Dictyostelium, where pulses of adenosine 3',5'-monophosphate (cAMP) are generated with a periodicity of 7 minutes. We have observed spontaneous oscillations in activation of the mitogen-activated protein (MAP) kinase ERK2 that occur in phase with peaks of cAMP, and we show that ERK2 modulates cAMP levels through the phosphodiesterase RegA. Computer modeling and simulations of the underlying circuit faithfully account for the ability of the cells to spontaneously generate periodic pulses during specific stages of development. Similar oscillatory processes may occur in cells of many different species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maeda, Mineko -- Lu, Sijie -- Shaulsky, Gad -- Miyazaki, Yuji -- Kuwayama, Hidekazu -- Tanaka, Yoshimasa -- Kuspa, Adam -- Loomis, William F -- GM52359/GM/NIGMS NIH HHS/ -- GM62350/GM/NIGMS NIH HHS/ -- R01 GM052359/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2004 May 7;304(5672):875-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Graduate School of Science, Osaka University, Machikaneyama-cho 1-16, Toyonaka, Osaka 560-0043, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15131307" target="_blank"〉PubMed〈/a〉
    Keywords: 3',5'-Cyclic-AMP Phosphodiesterases ; Adenylyl Cyclases/metabolism ; Animals ; Computer Simulation ; Cyclic AMP/*metabolism ; Cyclic AMP-Dependent Protein Kinases/genetics/*metabolism ; Dictyostelium/enzymology/genetics/growth & development/*metabolism ; Enzyme Activation ; Mitogen-Activated Protein Kinase 1/genetics/*metabolism ; Models, Biological ; Mutagenesis, Site-Directed ; Mutation ; Phosphorylation ; Protozoan Proteins/genetics/metabolism ; Receptors, Cyclic AMP/metabolism ; *Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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