Publication Date:
2006-06-10
Description:
The links between the cell cycle machinery and the cytoskeletal proteins controlling cytokinesis are poorly understood. The small guanine nucleotide triphosphate (GTP)-binding protein RhoA stimulates type II myosin contractility and formin-dependent assembly of the cytokinetic actin contractile ring. We found that budding yeast Polo-like kinase Cdc5 controls the targeting and activation of Rho1 (RhoA) at the division site via Rho1 guanine nucleotide exchange factors. This role of Cdc5 (Polo-like kinase) in regulating Rho1 is likely to be relevant to cytokinesis and asymmetric cell division in other organisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yoshida, Satoshi -- Kono, Keiko -- Lowery, Drew M -- Bartolini, Sara -- Yaffe, Michael B -- Ohya, Yoshikazu -- Pellman, David -- New York, N.Y. -- Science. 2006 Jul 7;313(5783):108-11. Epub 2006 Jun 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16763112" target="_blank"〉PubMed〈/a〉
Keywords:
Actins/metabolism
;
Amino Acid Motifs
;
Anaphase
;
Cell Cycle Proteins/chemistry/genetics/*metabolism
;
*Cytokinesis
;
Guanine Nucleotide Exchange Factors/chemistry/genetics/metabolism
;
Guanosine Triphosphate/metabolism
;
Microfilament Proteins/metabolism
;
Mitosis
;
Mutation
;
Phosphorylation
;
Protein Kinases/chemistry/genetics/*metabolism
;
Protein-Serine-Threonine Kinases
;
Recombinant Fusion Proteins/metabolism
;
Saccharomyces cerevisiae/*cytology/genetics/*metabolism
;
Saccharomyces cerevisiae Proteins/chemistry/genetics/*metabolism
;
Temperature
;
rho GTP-Binding Proteins/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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