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  • 1
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    Dynamic optimization of odor representations by slow temporal patterning of mitral cell activity (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-07
    Description: Mitral cells (MCs) in the olfactory bulb (OB) respond to odors with slow temporal firing patterns. The representation of each odor by activity patterns across the MC population thus changes continuously throughout a stimulus, in an odor-specific manner. In the zebrafish OB, we found that this distributed temporal patterning progressively reduced the similarity between ensemble representations of related odors, thereby making each odor's representation more specific over time. The tuning of individual MCs was not sharpened during this process. Hence, the individual responses of MCs did not become more specific, but the odor-coding MC assemblies changed such that their overlap decreased. This optimization of ensemble representations did not occur among olfactory afferents but resulted from OB circuit dynamics. Time can therefore gradually optimize stimulus representations in a sensory network.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Friedrich, R W -- Laurent, G -- New York, N.Y. -- Science. 2001 Feb 2;291(5505):889-94.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉California Institute of Technology, Division of Biology, MC 139-74, Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11157170" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids ; Animals ; Dendrites/physiology ; In Vitro Techniques ; Interneurons/physiology ; Membrane Potentials ; Neural Conduction ; Neural Inhibition ; Neurons/physiology ; *Odors ; Olfactory Bulb/*cytology/*physiology ; Olfactory Pathways/physiology ; Olfactory Receptor Neurons/physiology ; Patch-Clamp Techniques ; Receptors, Odorant/physiology ; Smell/*physiology ; Time Factors ; Zebrafish
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Oscillations and sparsening of odor representations in the mushroom body (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-07-20
    Description: In the insect olfactory system, oscillatory synchronization is functionally relevant and reflects the coherent activation of dynamic neural assemblies. We examined the role of such oscillatory synchronization in information transfer between networks in this system. The antennal lobe is the obligatory relay for olfactory afferent signals and generates oscillatory output. The mushroom body is responsible for formation and retrieval of olfactory and other memories. The format of odor representations differs significantly across these structures. Whereas representations are dense, dynamic, and seemingly redundant in the antennal lobe, they are sparse and carried by more selective neurons in the mushroom body. This transformation relies on a combination of oscillatory dynamics and intrinsic and circuit properties that act together to selectively filter and synthesize the output from the antennal lobe. These results provide direct support for the functional relevance of correlation codes and shed some light on the role of oscillatory synchronization in sensory networks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perez-Orive, Javier -- Mazor, Ofer -- Turner, Glenn C -- Cassenaer, Stijn -- Wilson, Rachel I -- Laurent, Gilles -- P41-RR09754/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2002 Jul 19;297(5580):359-65.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biology, 139-74, California Institute of Technology, Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12130775" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Electric Stimulation ; Electrodes ; Evoked Potentials ; Excitatory Postsynaptic Potentials ; Female ; Grasshoppers ; Interneurons/physiology ; Male ; Mushroom Bodies/*cytology/*physiology ; Nerve Net/*physiology ; Neural Inhibition ; Neurons/*physiology ; *Odors ; Patch-Clamp Techniques ; Picrotoxin/pharmacology ; Smell/*physiology ; Synaptic Transmission ; Time Factors ; gamma-Aminobutyric Acid/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Transformation of olfactory representations in the Drosophila antennal lobe (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-12-20
    Description: Molecular genetics has revealed a precise stereotypy in the projection of primary olfactory sensory neurons onto secondary neurons. A major challenge is to understand how this mapping translates into odor responses in these second-order neurons. We investigated this question in Drosophila using whole-cell recordings in vivo. We observe that monomolecular odors generally elicit responses in large ensembles of antennal lobe neurons. Comparison of odor-evoked activity from afferents and postsynaptic neurons in the same glomerulus revealed that second-order neurons display broader tuning and more complex responses than their primary afferents. This indicates a major transformation of odor representations, implicating lateral interactions within the antennal lobe.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, Rachel I -- Turner, Glenn C -- Laurent, Gilles -- New York, N.Y. -- Science. 2004 Jan 16;303(5656):366-70. Epub 2003 Dec 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biology, 139-74, California Institute of Technology, Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14684826" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Drosophila/anatomy & histology/*physiology ; Excitatory Postsynaptic Potentials ; GABA Antagonists/pharmacology ; GABA-A Receptor Antagonists ; Nervous System Physiological Phenomena ; Neural Inhibition ; Neurons, Afferent/*physiology ; *Odors ; Olfactory Pathways ; Olfactory Receptor Neurons/*physiology ; Patch-Clamp Techniques ; Picrotoxin/pharmacology ; Receptors, GABA-A/metabolism ; Sense Organs/physiology ; Smell/*physiology ; Synapses/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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