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  • 1
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    Evolution of a strain of CJD that induces BSE-like plaques (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-07-04
    Description: Bovine spongiform encephalopathy (BSE) has become a public health issue because a recently evolved BSE agent has infected people, yielding an unusual form of Creutzfeld-Jakob disease (CJD). A new CJD agent that provokes similar amyloid plaques and cerebellar pathology was serially propagated. First-passage rats showed obvious clinical signs and activated microglia but had negligible PrP-res (the more protease-resistant form of host PrP) or cerebellar lesions. Microglia and astrocytes may participate in strain selection because the agent evolved, stabilized, and reproducibly provoked BSE-like disease in subsequent passages. Early vacuolar change involving activated microglia and astrocytes preceded significant PrP-res accumulation by more than 50 days. These studies reveal several inflammatory host reactions to an exogenous agent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Manuelidis, L -- Fritch, W -- Xi, Y G -- NS12674/NS/NINDS NIH HHS/ -- NS34569/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1997 Jul 4;277(5322):94-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Neuropathology, Yale Medical School, 310 Cedar Street, New Haven, CT 06510, USA. laura.manuelidis@yale.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9204907" target="_blank"〉PubMed〈/a〉
    Keywords: Amyloid beta-Protein Precursor/analysis ; Animals ; Astrocytes/chemistry/*ultrastructure ; Brain/*pathology ; Brain Chemistry ; Cerebellum/chemistry/pathology ; Clusterin ; Creutzfeldt-Jakob Syndrome/metabolism/*pathology ; Cricetinae ; Cricetulus ; Encephalopathy, Bovine Spongiform/metabolism/*pathology ; Glial Fibrillary Acidic Protein/genetics/metabolism ; Glycoproteins/analysis ; Inflammation ; Macrophages/chemistry/ultrastructure ; Mice ; Mice, Inbred Strains ; Microglia/chemistry/*ultrastructure ; Microscopy, Electron ; *Molecular Chaperones ; PrPSc Proteins/*analysis/pathogenicity ; RNA/metabolism ; Rats ; Rats, Sprague-Dawley ; Time Factors ; Ubiquitins/analysis ; Vacuoles/ultrastructure ; Virulence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Reciprocal interference between specific CJD and scrapie agents in neural cell cultures (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-10-22
    Description: Infection of mice with an attenuated Creutzfeldt-Jakob disease agent (SY-CJD) interferes with superinfection by a more virulent human-derived CJD agent (FU-CJD) and does not require pathological prion protein (PrPres). Using a rapid coculture system, we found that a neural cell line free of immune system cells similarly supported substantial CJD agent interference without PrPres. In addition, SY-CJD prevented superinfection by sheep-derived Chandler (Ch) and 22L scrapie agents. However, only 22L and not Ch prevented FU-CJD infection, even though both scrapie strains provoked abundant PrPres. This relationship between particular strains of sheep- and human-derived agents is likely to affect their prevalence and epidemic spread.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nishida, Noriuki -- Katamine, Shigeru -- Manuelidis, Laura -- NS12674/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2005 Oct 21;310(5747):493-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Yale Medical School, New Haven, CT 06510, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16239476" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Coculture Techniques ; *Creutzfeldt-Jakob Syndrome ; Humans ; Mice ; Neurons/metabolism/*physiology ; PrPSc Proteins/metabolism/*pathogenicity ; Prions/metabolism/*pathogenicity/*physiology ; Scrapie ; Sheep ; Species Specificity ; Virulence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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