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  • 1
    Electronic Resource
    Electronic Resource
    SeBr3[AlBr4] und TeI3[AlI4] - zwei weitere Vertreter des SCl3[AlCl4]-Strukturtyps (1995)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 621 (1995), S. 1042-1046 
    Details
    ISSN: 0044-2313
    Keywords: Tribromoselenium (+) ; Triiodotellurium (+) ; Tetrabromoaluminate (-) ; Tetraiodoaluminate (-) ; synthesis ; crystal structure ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: SeBr3[AlBr4] and TeI3[AlI4] - two further Compounds in the SCl3[AlCl4] Structure TypeThe reaction of SeBr4 and AlBr3 in a closed glass ampoule at 150°C yields quantitatively SeBr3[AlBr4] in form of yellow moisture sensitive crystals. From Te, two equivalents of I2, and AlI3 one obtains TeI3[AlI4] in form of dark red, moisture sensitive crystals. Both compounds crystallize monoclinic in the space group Pc (SeBr3[AlBr4]: a = 670.7(7) pm, b = 663.9(5) pm, c = 1 428.6(2) pm, β = 101.21(9)°, TeI3[AlI4]: a = 731.9(1) pm, b = 730.8(1) pm, c = 1 565.5(3) pm, β = 102.01(2)°). They are isotypic and have the SCl3[AlCl4] structure type. The structures are built of tetrahedral AlX4- ions and of pyramidal EX3+ ions (E = S, Se, Te; X = Cl, Br, I). The chalcogen atoms are additionally coordinated by halogen atoms of surrounding AlX4- ions, corresponding to a strongly distorted octahedral coordination EX3+3.
    Notes: Durch Reaktion von SeBr4 mit AlBr3 in einer geschlossenen Ampulle bei 150°C entsteht SeBr3[AlBr4] in Form gelber, hydrolyseempfindlicher Kristalle in quantitativer Ausbeute. Aus Te, AlI3 und zwei Äquivalenten I2 entsteht unter gleichen Bedingungen TeI3[AlI4] in Form dunkelroter, ebenfalls hydrolyseempfindlicher Kristalle. Beide Verbindungen kristallisieren monoklin, Raumgruppe Pc (SeBr3[AlBr4]: a = 670,7(7) pm, b = 663,9(5) pm, c = 1 428,6(2) pm, β = 101,21(9)°, TeI3[AlI4]: a = 731,9(1) pm, b = 730,8(1) pm, c = 1 565,5(3) pm, β = 102,01(2)°). Sie sind isotyp zu SCl3[AlCl4]. Die Strukturen sind aus tetraedrischen AlX4--Ionen und aus pyramidalen EX3+-Ionen (E = S, Se, Te; X = Cl, Br, I) aufgebaut. Das Chalkogen ist dabei von Halogenatomen benachbarter AlX4--Ionen zusätzlich so koordiniert, daß es eine stark verzerrte oktaedrische EX3+3-Koordination aufweist.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19956210625
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  • 2
    Electronic Resource
    Electronic Resource
    Der erste Metallkomplex mit neutralem 1,2-Bis(phenyltriazeno)benzol als Ligand: Synthese und Struktur von [Cd{PhN3(H)C6H4N3(H)Ph}{PhN3C6H4N3(H)Ph}2] (1996)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 622 (1996), S. 1177-1181 
    Details
    ISSN: 0044-2313
    Keywords: Cadmium(II) complex ; 1,2-bis(phenyltriazeno)benzene ligand ; synthesis ; crystal structure ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The First Metal Complex with Neutral 1,2-Bis(phenyltriazeno)-benzene as Ligand: Synthesis and Crystal Structure of [Cd{PhN3(H)C6H4N3(H)Ph}{PhN3C6H4N3(H)Ph}2][Cd{PhN3(H)C6H4N3(H)Ph}{PhN3C6H4N3(H)Ph}2] is obtained in aqueous ammonia by the reaction of CdSO4 with an excess of 1,2-bis(phenyltriazeno)benzene. It forms orange red, air stable prismatic crystals with the monoclinic space group P21/c and a = 1217.7(2); b = 2161.8(6); c = 2008.3(5) pm; β = 100.07(6)º; Z = 4. The compound is composed of mononuclear complexes in which the Cd atom is coordinated by one chelating bis(phenyltriazeno)benzene and two monodentate 1-phenyltriazenido-2-phenyltriazeno benzene anions in a distorted tetrahedral arrangement. The Cd - N distances are in the range of 220.7 to 239.7 pm.
    Notes: [Cd{PhN3(H)C6H4N3(H)Ph}{PhN3C6H4N3(H)Ph}2] entsteht in ammoniakalischer Lösung aus CdSO4 und einem Überschuß an 1,2-Bis(phenyltriazeno)benzol in Form orangeroter, luftstabiler Kristalle. Es kristallisiert monoklin in der Raumgruppe P21/c mit a = 1217,7(2); b = 2161,8(6); c = 2008,3(5) pm; β = 100,07(6)º; Z = 4. Die Verbindung bildet einkernige Komplexe, in denen das Cd-Kation von einem chelatartig gebundenen Bis(phenyltriazeno)benzol und zwei einzähnig koordinierenden 1-Phenyltriazenido-2-phenyltriazenobenzol-Anionen verzerrt tetraedrisch umgeben ist. Die Cd - N-Abstände liegen im Bereich zwischen 220,7 und 239,7 pm.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19966220712
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  • 3
    Electronic Resource
    Electronic Resource
    Tellur-Polykationen stabilisiert durch Nioboxidhalogenide: Synthese und Kristallstrukturen von Te7NbOBr5 und Te7NbOCl5Professor Heinrich Oppermann zum 60. Geburtstag gewidmet (1994)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 620 (1994), S. 1971-1975 
    Details
    ISSN: 0044-2313
    Keywords: Tellurium ; niobium oxytrihalides ; poly(heptatellurium(2+)) ; tetrachlorooxoniobate (1-) ; tetrabromooxoniobate (1-) ; synthesis ; crystal structure ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Tellurium Cations stabilized by Niobium Oxytrihalides: Synthesis and Crystal Structure of Te7NbOBr5 and Te7NbOCl5The reaction of Te2Br with NbOBr3 in a sealed evacuated glass ampoule at 225°C yields Te7NbOBr5 in form of bright black needles. Te7NbOCl5 is obtained from tellurium, TeCl4 and NbOCl3 at 220°C. Both compounds crystallize orthorhombic in the space group Pcca (Te7NbOBr5: a = 2 651,9(4) pm, b = 836.6(1) pm, c = 794.6(1) pm; Te7NbOCl5: a = 2 597.7(5) pm, b = 805.1(1) pm, c = 791.2(1) pm). The crystal structure determinations show that Te7NbOBr5 and Te7NbOCl5 are built of one-dimensional polymeric tellurium cations, one-dimensional associated pyramidal NbOX4 groups (X = Cl, Br) and isolated halide anions. Magnetic properties of Te7NbOX5 were determined and confirm the expected diamagnetism. Te7NbOX5 can thus be formulated as ∞1[Te72+] ∞1[NbOX4-] (X-). The charge distribution in the structure type Te7MOX5 (M = W, Nb; X = Cl, Br) became clear by synthesis and characterisation of the two niobium containing compounds.
    Notes: Durch Reaktion von Te2Br mit NbOBr3 in einer evakuierten Glasampulle bei 225°C entsteht Te7NbOBr5 in Form von schwarzglänzenden, stäbchenförmigen Kristallen. Te7NbOCl5 wird aus Te, TeCl4 und NbOCl3 bei 220°C erhalten. Beide Verbindungen kristallisieren im orthorhombischen Kristallsystem in der Raumgruppe Pcca (Te7NbOBr5: a = 2 651,9(4) pm, b = 836,6(1) pm, c = 794,6(1) pm; Te7NbOCl5: a = 2 597,7(5) pm, b = 805,1(1) pm, c = 791,2(1) pm). Die Kristallstrukturanalysen zeigen, daß Te7NbOBr5 und Te7NbOCl5 aus eindimensionalen polymeren Tellur-Kationen, eindimensionalen Strängen von pyramidalen, über O-Atome assoziierten NbOX4-Einheiten und aus isolierten Halogenidionen aufgebaut sind. Magnetische Messungen bestätigen den erwarteten Diamagnetismus und zeigen, daß Nb in der formalen Oxidationsstufe + V vorliegt. Die ionische Schreibweise lautet daher ∞1[Te72+] ∞1[NbOX4-] (X-). Die Synthese und Charakterisierung der beiden niobhaltigen Vertreter klärt die Ladungsverteilung im Strukturtyp Te7MOX5 (M = W, Nb; X = Cl, Br).
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19946201122
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  • 4
    Electronic Resource
    Electronic Resource
    Synthese und Kristallstruktur von Cu4[PhN3C6H4N3(H)Ph]4(μ2-O)2, einem vierkernigen Kupfer(II)-Komplex mit 1-Phenyltriazenido-2-phenyltriazenobenzol als Ligand (1994)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 620 (1994), S. 107-111 
    Details
    ISSN: 0044-2313
    Keywords: Tetrameric copper(II) complex ; μ2-oxo ligand ; 1-phenyltriazenido-2-phenyltriazeno benzene ligand ; synthesis ; crystal structure ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Synthesis and Crystal Structure of Cu4[PhN3C6H4N3(H)Ph]4(μ2-O)2, a Tetranuclear Copper(II) Complex with 1-Phenyltriazenido-2-phenyltriazeno-benzene as LigandCu4[PhN3C6H4N3(H)Ph]4(μ-O)2 (1) results from the reaction of an aqueous solution of [Cu(NH3)4]2+ with 1,2-bis(phenyltriazeno)benzene in ether. 1 crystallizes in the orthorhombic space group Pba2 with the lattice parameters a = 1661.5(5), b = 1914.7(7), c = 1269.2(5) pm; Z = 2. In the tetrameric complex with the symmetry C2 the Cu2+ cations form a tetrahedron (Cu—Cu: 298.3(1)-337.1(1) pm). The μ2-oxo ligands occupy the twofold axis and bridge two opposite edges of the Cu4 tetrahedron (Cu—O: 190.0(3) and 192.5(4) pm). The 1-phenyltriazenido-2-phenyltriazeno benzene anions bridge two Cu2+ ions chelating one metal ion and coordinating monodentate the neighbouring one (Cu—N: 191.0(5)-204.1(4) pm).
    Notes: Cu4[PhN3C6H4N3(H)Ph]4(μ-O)2 (1) entsteht bei der Umsetzung einer wäßrigen Lösung von [Cu(NH3)4]2+ mit 1,2-Bis(phenyltriazeno)benzol in Ether. 1 kristallisiert orthorhombisch in der Raumgruppe Pba2 mit den Gitterkonstanten a = 1661,5(5); b = 1914,7(7); c = 1269,2(5) pm; Z = 2. Im tetrameren Komplex mit der Symmetrie C2 bilden die Cu2+-Ionen ein Tetraeder (Cu—Cu: 298,3(1)-337,1(1) pm). Die μ2-Oxoliganden liegen auf der C2-Achse und überbrücken zwei gegenüberliegende Tetraederkanten (Cu—O: 190,0(3) und 192,5(4) pm). Die 1-Phenyltriazenido-2-phenyltriazeno-benzol-Anionen verbrücken benachbarte Cu2+-Ionen, die sie einerseits chelatisierend und andererseits einzähnig koordinieren (Cu—N: 191,0(5)-204,1(4) pm).
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19946200117
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  • 5
    Electronic Resource
    Electronic Resource
    Das prismatische Te62+-Ion in der Struktur von Te6(NbOCl4)2Professor Hans Georg von Schnering zum 65. Geburtstag gewidmet (1996)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 622 (1996), S. 823-828 
    Details
    ISSN: 0044-2313
    Keywords: Tellurium ; niobium oxytrihalides ; hexatellurium(2+) ; tetrachlorooxoniobate (1-) ; synthesis ; crystal structure ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The Prismatic Te62+ Ion in the Structure of Te6(NbOCl4)2Te6(NbOCl4)2 is obtained from Te, TeCl4 and NbOCl3 at 200°C. It crystallizes triclinic, space group P1 (a = 915,5(4) pm, b = 1655,3(6) pm, c = 3134,4(9) pm, α = 42,62(2)°, β = 117,12(6)°, γ = 138,24(8)°). The crystal structure analysis shows, that the structure is built of one-dimensional polymeric ∞1[NbOCl4-] chains in which the monomers are linked via linear O—Nb—O-bridges and from discrete Te62+ polycations that are also arranged in strands, but without significant interactions. The structure is closley related but not isotypic to the previously reported tungsten containing analogue Te6(WOCl4)2 (monoclinic, P21/c). A comparison of the two structures shows that rotations of the cationic strands relative to the anionic strands lead to different cation-anion interactions.
    Notes: Te6(NbOCl4)2 wird aus Te, TeCl4 und NbOCl3 bei 200°C erhalten. Es kristallisiert triklin, P1, a = 915,5(4) pm, b = 1655,3(6) pm, c = 3134,4(9) pm, α = 42,62(2)°, β = 117,12(6)°, γ = 138,24(8)°. Die Kristallstrukturanalyse zeigt, daß die Struktur aus eindimensional-polymeren, über O-Atome verknüpften ∞1[NbOCl4-]-Strängen und aus diskreten, strangartig angeordneten Te62+-Polykationen aufgebaut ist. Die Struktur ist eng verwandt, aber nicht isotyp mit derjenigen der analogen wolframhaltigen Verbindung Te6(WOCl4)2 (monoklin, P21/c). Ein Strukturvergleich zeigt, daß Verdrehungen der Kationenstränge relativ zu den Anionensträngen zu unterschiedlichen Kation-Anionwechselwirkungen führen.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19966220513
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  • 6
    Electronic Resource
    Electronic Resource
    Darstellung und Kristallstruktur von [Tl2(PhN3C6H4CH2C6H4N3Ph)3], einem zweikernigen TlIII-Komplex mit einem neuen, überbrückenden Bistriazenido-Liganden (1997)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 623 (1997), S. 65-68 
    Details
    ISSN: 0044-2313
    Keywords: Thallium(III) complex ; di(4,4′-phenyltriazenido)-phenylmethane ligand ; synthesis ; crystal structure ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Synthesis and Crystal Structure of [Tl2(PhN3C6H4CH2C6H4N3Ph)3], a Dinuclear TlIII Complex with a Novel, Bridging Bistriazenido LigandTris[di(4,4′-phenyltriazenido)phenylmethane]-dithallium(III) is formed by the reaction of TlNO3 with di(4,4′-phenyltriazeno)phenylmethane in the presence of NaOH and air in an ethanol/H2O mixture. The compound is obtained as red, needlelike crystals from THF-hexane. It crystallizes monoclinic, space group I 2/a (a = 1375.2(5) pm, b = 2615(2) pm, c = 1957.0(8) pm, β = 93.49(3)°) with four dinuclear complexes in the unit cell. Each complex contains three doubly deprotonated bistriazenido ions (PhN3C6H4CH2C6H4N3Ph)2- and two Tl3+ ions. The Tl ions are each coordinated by three chelating triazenido groups resulting in a trigonal prismatic coordination of six N atoms. The Tl-N distances vary between 227 and 239 pm, all N-N distance of the triazenido groups are equal within standard deviations with a mean of 130 pm.
    Notes: Tris[di(4,4′-phenyltriazenido)phenylmethan]-di-thallium(III) entsteht durch Reaktion von TlNO3 mit Di(4,4′-phenyltriazeno)phenylmethan in Gegenwart von NaOH und Luft in einem Ethanol/H2O-Gemisch. Die Verbindung kann in Form roter, nudelförmiger Kristalle aus einem THF/Hexan-Gemisch erhalten werden. Sie kristallisiert monoklin in der Raumgruppe I 2/a mit den Gitterkonstanten a = 1375,2(5) pm, b = 2615(2) pm, c = 1957,0(8) pm, β = 93,49(3)° mit vier zweikernigen Komplexen in der Elementarzelle, von denen jeder aus drei doppelt deprotonierten Bistriazenido-Ionen (PhN3C6H4CH2C6H4N3Ph)2- und zwei Tl3+-Ionen aufgebaut ist. Die Tl-Ionen sind jeweils von drei Triazenidogruppen chelatförmig koordiniert, wodurch für die Kationen ein trigonal prismatisches Koordinationspolyeder aus sechs N-Atomen resultiert. Die Tl-N-Abstände variieren zwischen 227 und 239 pm, alle N-N-Abstände in den Triazenidogruppen sind innerhalb der Standardabweichungen gleich und betrugen im Mittel 130 pm.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19976230111
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  • 7
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    Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs (1999)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1999-09-08
    Description: A mevalonate-independent pathway of isoprenoid biosynthesis present in Plasmodium falciparum was shown to represent an effective target for chemotherapy of malaria. This pathway includes 1-deoxy-D-xylulose 5-phosphate (DOXP) as a key metabolite. The presence of two genes encoding the enzymes DOXP synthase and DOXP reductoisomerase suggests that isoprenoid biosynthesis in P. falciparum depends on the DOXP pathway. This pathway is probably located in the apicoplast. The recombinant P. falciparum DOXP reductoisomerase was inhibited by fosmidomycin and its derivative, FR-900098. Both drugs suppressed the in vitro growth of multidrug-resistant P. falciparum strains. After therapy with these drugs, mice infected with the rodent malaria parasite P. vinckei were cured.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jomaa, H -- Wiesner, J -- Sanderbrand, S -- Altincicek, B -- Weidemeyer, C -- Hintz, M -- Turbachova, I -- Eberl, M -- Zeidler, J -- Lichtenthaler, H K -- Soldati, D -- Beck, E -- New York, N.Y. -- Science. 1999 Sep 3;285(5433):1573-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Biochemistry, Academic Hospital Centre, Justus-Liebig-University, Friedrichstrasse 24, D-35392 Giessen, Germany. hassan.jomaa@biochemie.med.uni-giessen.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10477522" target="_blank"〉PubMed〈/a〉
    Keywords: Aldose-Ketose Isomerases/*antagonists & inhibitors/chemistry/genetics/metabolism ; Amino Acid Sequence ; Animals ; Antimalarials/*pharmacology ; Cloning, Molecular ; Enzyme Inhibitors/pharmacology ; Fosfomycin/*analogs & derivatives/pharmacology ; Genes, Protozoan ; *Hemiterpenes ; Malaria/*drug therapy/parasitology ; Malaria, Falciparum/drug therapy/parasitology ; Mevalonic Acid/metabolism ; Mice ; Molecular Sequence Data ; Multienzyme Complexes/*antagonists & inhibitors/chemistry/genetics/metabolism ; Organelles/drug effects/metabolism ; Organophosphorus Compounds/metabolism ; Oxidoreductases/*antagonists & inhibitors/chemistry/genetics/metabolism ; Pentosephosphates/*metabolism ; Plasmodium falciparum/*drug effects/genetics/metabolism ; Recombinant Proteins/antagonists & inhibitors/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Terpenes/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Reptilian heart development and the molecular basis of cardiac chamber evolution (2009)
    Nature Publishing Group (NPG)
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    Publication Date: 2009-09-04
    Description: The emergence of terrestrial life witnessed the need for more sophisticated circulatory systems. This has evolved in birds, mammals and crocodilians into complete septation of the heart into left and right sides, allowing separate pulmonary and systemic circulatory systems, a key requirement for the evolution of endothermy. However, the evolution of the amniote heart is poorly understood. Reptilian hearts have been the subject of debate in the context of the evolution of cardiac septation: do they possess a single ventricular chamber or two incompletely septated ventricles? Here we examine heart development in the red-eared slider turtle, Trachemys scripta elegans (a chelonian), and the green anole, Anolis carolinensis (a squamate), focusing on gene expression in the developing ventricles. Both reptiles initially form a ventricular chamber that homogenously expresses the T-box transcription factor gene Tbx5. In contrast, in birds and mammals, Tbx5 is restricted to left ventricle precursors. In later stages, Tbx5 expression in the turtle (but not anole) heart is gradually restricted to a distinct left ventricle, forming a left-right gradient. This suggests that Tbx5 expression was refined during evolution to pattern the ventricles. In support of this hypothesis, we show that loss of Tbx5 in the mouse ventricle results in a single chamber lacking distinct identity, indicating a requirement for Tbx5 in septation. Importantly, misexpression of Tbx5 throughout the developing myocardium to mimic the reptilian expression pattern also results in a single mispatterned ventricular chamber lacking septation. Thus ventricular septation is established by a steep and correctly positioned Tbx5 gradient. Our findings provide a molecular mechanism for the evolution of the amniote ventricle, and support the concept that altered expression of developmental regulators is a key mechanism of vertebrate evolution.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753965/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753965/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koshiba-Takeuchi, Kazuko -- Mori, Alessandro D -- Kaynak, Bogac L -- Cebra-Thomas, Judith -- Sukonnik, Tatyana -- Georges, Romain O -- Latham, Stephany -- Beck, Laurel -- Henkelman, R Mark -- Black, Brian L -- Olson, Eric N -- Wade, Juli -- Takeuchi, Jun K -- Nemer, Mona -- Gilbert, Scott F -- Bruneau, Benoit G -- C06 RR018928/RR/NCRR NIH HHS/ -- P01 HL089707/HL/NHLBI NIH HHS/ -- P01 HL089707-01A1/HL/NHLBI NIH HHS/ -- P01HL089707/HL/NHLBI NIH HHS/ -- R01 HL064658/HL/NHLBI NIH HHS/ -- England -- Nature. 2009 Sep 3;461(7260):95-8. doi: 10.1038/nature08324.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19727199" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chick Embryo ; *Evolution, Molecular ; Gene Expression Regulation, Developmental ; Heart/anatomy & histology/*embryology ; Lizards/anatomy & histology/*embryology/genetics ; Mice ; Organogenesis ; T-Box Domain Proteins/deficiency/genetics/metabolism ; Turtles/anatomy & histology/*embryology/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 9
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    Intravascular danger signals guide neutrophils to sites of sterile inflammation (2010)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2010-10-16
    Description: Neutrophils are recruited from the blood to sites of sterile inflammation, where they contribute to wound healing but may also cause tissue damage. By using spinning disk confocal intravital microscopy, we examined the kinetics and molecular mechanisms of neutrophil recruitment to sites of focal hepatic necrosis in vivo. Adenosine triphosphate released from necrotic cells activated the Nlrp3 inflammasome to generate an inflammatory microenvironment that alerted circulating neutrophils to adhere within liver sinusoids. Subsequently, generation of an intravascular chemokine gradient directed neutrophil migration through healthy tissue toward foci of damage. Lastly, formyl-peptide signals released from necrotic cells guided neutrophils through nonperfused sinusoids into the injury. Thus, dynamic in vivo imaging revealed a multistep hierarchy of directional cues that guide neutrophil localization to sites of sterile inflammation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McDonald, Braedon -- Pittman, Keir -- Menezes, Gustavo B -- Hirota, Simon A -- Slaba, Ingrid -- Waterhouse, Christopher C M -- Beck, Paul L -- Muruve, Daniel A -- Kubes, Paul -- Canadian Institutes of Health Research/Canada -- New York, N.Y. -- Science. 2010 Oct 15;330(6002):362-6. doi: 10.1126/science.1195491.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Immunology Research Group, University of Calgary, Alberta T2N 4N1, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20947763" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Animals ; Carrier Proteins/metabolism ; Cell Adhesion ; Chemokine CXCL2/metabolism ; Chemokines/metabolism ; Chemotaxis, Leukocyte ; Cues ; Endothelium, Vascular/physiology ; Inflammation/*immunology/metabolism/*pathology ; Kinetics ; Liver/blood supply/*immunology/metabolism/*pathology ; Liver Diseases/*immunology/metabolism/*pathology ; Macrophage-1 Antigen/physiology ; Mice ; Microscopy/methods ; Microscopy, Confocal ; Microvessels/physiology ; Necrosis ; *Neutrophil Infiltration ; Neutrophils/physiology ; Peptides/metabolism ; Receptors, Formyl Peptide/metabolism ; Receptors, Interleukin-8B/metabolism ; Receptors, Purinergic P2/metabolism ; Receptors, Purinergic P2X7 ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    The C-terminal domain of RNA polymerase II is modified by site-specific methylation (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-04-02
    Description: The carboxy-terminal domain (CTD) of RNA polymerase II (RNAPII) in mammals undergoes extensive posttranslational modification, which is essential for transcriptional initiation and elongation. Here, we show that the CTD of RNAPII is methylated at a single arginine (R1810) by the coactivator-associated arginine methyltransferase 1 (CARM1). Although methylation at R1810 is present on the hyperphosphorylated form of RNAPII in vivo, Ser2 or Ser5 phosphorylation inhibits CARM1 activity toward this site in vitro, suggesting that methylation occurs before transcription initiation. Mutation of R1810 results in the misexpression of a variety of small nuclear RNAs and small nucleolar RNAs, an effect that is also observed in Carm1(-/-) mouse embryo fibroblasts. These results demonstrate that CTD methylation facilitates the expression of select RNAs, perhaps serving to discriminate the RNAPII-associated machinery recruited to distinct gene types.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773223/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773223/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sims, Robert J 3rd -- Rojas, Luis Alejandro -- Beck, David -- Bonasio, Roberto -- Schuller, Roland -- Drury, William J 3rd -- Eick, Dirk -- Reinberg, Danny -- F32 GM071166/GM/NIGMS NIH HHS/ -- GM-37120/GM/NIGMS NIH HHS/ -- GM-71166/GM/NIGMS NIH HHS/ -- R01 GM037120/GM/NIGMS NIH HHS/ -- R37 GM037120/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Apr 1;332(6025):99-103. doi: 10.1126/science.1202663.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute (HHMI), Department of Biochemistry, New York University School of Medicine, 522 First Avenue, Smilow 211, New York, NY 10016, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21454787" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arginine/metabolism ; Cell Line ; HeLa Cells ; Humans ; Methylation ; Mice ; Mutation ; Protein Interaction Domains and Motifs ; Protein Structure, Tertiary ; Protein-Arginine N-Methyltransferases/metabolism ; RNA Polymerase II/genetics/*metabolism ; RNA, Small Nuclear/metabolism ; RNA, Small Nucleolar/metabolism ; Recombinant Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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