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    Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-03-17
    Description: Most of the immunoglobulin A (IgA) in the gut is generated by B cells in the germinal centers of Peyer's patches through a process that requires the presence of CD4+ follicular B helper T(TFH) cells. The nature of these T(FH) cells in Peyer's patches has been elusive. Here, we demonstrate that suppressive Foxp3+CD4+ T cells can differentiate into TFH cells in mouse Peyer's patches. The conversion of Foxp3+ T cells into TFH cells requires the loss of Foxp3 expression and subsequent interaction with B cells. Thus, environmental cues present in gut Peyer's patches promote the selective differentiation of distinct helper T cell subsets, such as TFH cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tsuji, Masayuki -- Komatsu, Noriko -- Kawamoto, Shimpei -- Suzuki, Keiichiro -- Kanagawa, Osami -- Honjo, Tasuku -- Hori, Shohei -- Fagarasan, Sidonia -- New York, N.Y. -- Science. 2009 Mar 13;323(5920):1488-92. doi: 10.1126/science.1169152.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Mucosal Immunity, RIKEN, Yokohama 1-7-22, Tsurumi, Yokohama, 230-0045, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19286559" target="_blank"〉PubMed〈/a〉
    Keywords: Adoptive Transfer ; Animals ; Antigens, CD40/metabolism ; B-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/cytology/*immunology/metabolism ; Cell Differentiation ; Dendritic Cells/cytology/immunology ; Down-Regulation ; Forkhead Transcription Factors/genetics/*metabolism ; Gene Expression Profiling ; Germinal Center/immunology ; Immunoglobulin A, Secretory/biosynthesis ; Intestine, Small/cytology/immunology ; Lymph Nodes/cytology/immunology ; Lymphocyte Activation ; Mice ; Mice, Transgenic ; Peyer's Patches/cytology/*immunology ; Spleen/cytology/immunology ; T-Lymphocyte Subsets/cytology/*immunology/metabolism ; T-Lymphocytes, Helper-Inducer/cytology/*immunology/metabolism ; T-Lymphocytes, Regulatory/cytology/*immunology/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Control of regulatory T cell development by the transcription factor Foxp3 (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-01-11
    Description: Regulatory T cells engage in the maintenance of immunological self-tolerance by actively suppressing self-reactive lymphocytes. Little is known, however, about the molecular mechanism of their development. Here we show that Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4+ regulatory T cells. Furthermore, retroviral gene transfer of Foxp3 converts naive T cells toward a regulatory T cell phenotype similar to that of naturally occurring CD4+ regulatory T cells. Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hori, Shohei -- Nomura, Takashi -- Sakaguchi, Shimon -- New York, N.Y. -- Science. 2003 Feb 14;299(5609):1057-61. Epub 2003 Jan 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230-0045, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12522256" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD/analysis ; Autoimmune Diseases/immunology/prevention & control ; CD4-Positive T-Lymphocytes/immunology ; Cytokines/biosynthesis ; DNA-Binding Proteins/genetics/*metabolism ; Forkhead Transcription Factors ; Gastritis/immunology/prevention & control ; *Immune Tolerance ; Inflammatory Bowel Diseases/immunology/prevention & control ; Lymphocyte Activation ; Mice ; Mice, Inbred BALB C ; Mice, SCID ; Mice, Transgenic ; Mutation ; Receptors, Antigen, T-Cell/immunology ; Receptors, Interleukin-2/analysis ; Recombinant Fusion Proteins/metabolism ; Self Tolerance ; T-Lymphocyte Subsets/cytology/immunology ; T-Lymphocytes/immunology ; T-Lymphocytes, Regulatory/*immunology/*metabolism ; Thymus Gland/cytology/metabolism ; Transduction, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
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