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  • 1
    Electronic Resource
    Electronic Resource
    Absence of a significant pharmacokinetic interaction between hydrochlorothiazide and triamterene when coadministered (1984)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 12 (1984), S. 575-586 
    Details
    ISSN: 1573-8744
    Keywords: hydrochlorothiazide ; triamterene ; hydroxytriamterene sulfate ; pharmacokinetics ; bioavailability ; renal clearance ; interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Hydrochlorothiazide, triamterene, and hydroxytriamterene sulfate were monitored in the plasma and urine of 24 healthy young men taking single doses of a liquid preparation containing both hydrochlorothiazide and triameterene, liquid preparations containing either of these drugs alone, and a combination tablet recently formulated with a dose ratio of hydrochlorothiazide: triamterene (1∶1,5) found to give optimal potassium-sparing effect. In contradiction to a recent publication, no interaction between the drugs affecting the bioavailability or renal clearance of either could be demonstrated. The previous report of drug-drug interaction probably arose from formulationrelated problems with bioavailability from the two capsule and two tablet products which had been studied. A well-formulated hydrochlorothiazide-triamterene combination tablet promotes plasma concentrations and urinary excretion of hydrochlorothiazide, triamterene, and hydroxytriamterene sulfate which are virtually identical to those seen after either a combination liquid dosage form or simple liquid forms containing only one of the two drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01059553
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of Formulation and Food on the Absorption of Hydrochlorothiazide and Triamterene or Amiloride from Combination Diuretic Products (1987)
    Springer
    Pharmaceutical research 4 (1987), S. 348-352 
    Details
    ISSN: 1573-904X
    Keywords: hydrochlorothiazide ; triamterene ; Dyazide ; Maxzide ; amiloride ; Moduretic ; food–drug interactions ; food-formulation interactions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The absorption of three combination formulations of hydrochlorothiazide and either triamterene or amiloride was studied over a 5-year period in seven separate investigations under varying conditions of food and fasting. The most widely prescribed combination, containing 25 mg of hydrochlorothiazide and 50 mg of triamterene, demonstrated impaired absorption in the fasting state that was partially corrected by the addition of a breakfast high in fat. The increase in the fat content of the food appeared to correlate directly with the amount of both drugs absorbed from this formulation. The second formulation studied, a new combination formulation of 50 mg of hydrochlorothiazide and 75 mg of triamterene, demonstrated acceptable absorption in the fasting state that was not altered by the concurrent administration of a high-fat breakfast. The absorption of the third formulation, a combination of 50 mg hydrochlorothiazide and 5 mg amiloride, was acceptable in the fasting state and demonstrated a slight reduction in the absorption of the amiloride component when administered concurrently with a high-fat meal. The clinical and biopharmaceutic implications of these observations are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016409606936
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  • 3
    Electronic Resource
    Electronic Resource
    Novel 130-kDa rat liver myosin-1 will translocate actin filaments (1994)
    New York, NY : Wiley-Blackwell
    Cell Motility and the Cytoskeleton 27 (1994), S. 41-48 
    Details
    ISSN: 0886-1544
    Keywords: myosin-1 ; motility ; F-actin ; liver ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: We have recently purified and characterized from rat liver, polypeptides of 110-kDa and 130-kDa which possess several characteristics of myosin-1 [Coluccio and Conaty: Cell Motil. Cytoskeleton 24:189-199, 1993]. What roles these myosin-1 molecules play in hepatocytes is not yet defined. One hypothesis is that they are involved in either intracellular transport or locomotion. As a first step in establishing their function, we have investigated whether these molecules are capable of supporting motility in vitro. Our results clearly demonstrate that the isolated 130-kDa-calmodulin complex will translocate filaments at a rate of 0.03-0.05 μ/sec; motility is inhibited in free calcium ion concentrations above 0.1 μM. This inhibition is reversed with the addition of exogenous calmodulin. These results provide supporting evidence of a motile role for the 130-kDa-calmodulin complex in vivo. This is the first demonstration that in higher eukaryotes, myosin-1 from a tissue other than intestine will support motility. Partial peptide sequence analysis indicates that the 130-kDa polypeptide resembles the recently described myr 1 [Ruppert et al.: J. Cell Biol. 120:1393-1403, 1993] or MM1α [Sherr et al.: J. Cell Biol. 1405-1416, 1993] gene product. © 1994 Wiley-Liss, Inc.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cm.970270105
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  • 4
    Electronic Resource
    Electronic Resource
    Nm23/nucleoside diphosphate kinase: Toward a structural and biochemical understanding of its biological functions (1995)
    New York, NY : Wiley-Blackwell
    BioEssays 17 (1995), S. 53-62 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The nm23 gene, a putative metastasis suppressor gene, was originally identified by its reduced expression in highly metastatic K-1735 murine melanoma cell lines, as compared to related, low metastatic melanoma cell lines. Transfection of nm23 cDNA has been reported to suppress malignant progression in Drosophila and mammalian cells. Highly conserved homologues of nm23 have been found in organisms ranging from the prokaryote Myxococcus xanthus to Drosophila, where the gene is involved in normal development and differentiation. The product of the nm23 gene exhibits a nucleoside diphosphate kinase activity, yet the nucleoside diphosphate kinase activity of Nm23 does not correlate with its apparent biological functions. We review recent cellular, genetic, biochemical and X-ray crystallographic data to formulate and evaluate hypotheses concerning the molecular mechanism of nm23 action.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950170111
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  • 5
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    Silicon Carbide Transistor For Detecting Hydrocarbon Gases (1996)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: Proposed silicon carbide variable-potential insulated-gate field-effect transistor specially designed for use in measuring concentrations of hydrocarbon gases. Devices like this prove useful numerous automotive, industrial, aeronautical, and environmental monitoring applications.
    Keywords: PHYSICAL SCIENCES
    Type: NPO-19428 , NASA Tech Briefs (ISSN 0145-319X); 20; 3; P. 55
    Format: text
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  • 6
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    Improved Liquid-Electrode/Solid-Electrolyte Cell (1990)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: Organic liquid in cathode extends working life. Rechargeable solid-electrolyte electrochemical cell includes novel mixture of organic and inorganic materials in liquid cathode. Operates at temperature about 120 to 170 degrees C lower than sodium/sulfur cells. Offers energy density comparable to that of sodium/sulfur cells - about 10 Wh/kg - and suited to such applications as military systems and electric vehicles.
    Keywords: PHYSICAL SCIENCES
    Type: NPO-17604 , NASA Tech Briefs (ISSN 0145-319X); 14; 4; P. 51
    Format: text
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  • 7
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    Vapor-Exposure Cell For Testing Thin-Film Electrodes (1993)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: Vapor-exposure test cell (VETC) designed to be used in testing thin-film electrodes on solid electrolytes electrochemically at high temperature. Use of VETC much simpler and less expensive than testing alkali-metal thermal-to-electric converter (AMTEC) fuel cell, electrolysis cell, or other entire device containing solid electrolyte and electrodes of material and configuration to be characterized.
    Keywords: PHYSICAL SCIENCES
    Type: NPO-18620 , NASA Tech Briefs (ISSN 0145-319X); 17; 9; P. 80
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  • 8
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    Series-Connected Vapor/Vapor AMTEC Cells (1993)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: Size and weight reduced; operating lifetime increased. Developmental alkali-metal thermal-to-electric converter (AMTEC) in which cells fed from common supply of high-pressure sodium vapor and connected electrically in series. No liquid sodium makes contact with any part of AMTEC cells. Sodium vapor supplied to solid electrolyte of each cell through porous metal anode on upstream side. Proposed design reduces need for high-temperature feedthroughs in that cells internally connected. Power withdrawn through feedthrough at lower temperature without significant thermal loss.
    Keywords: PHYSICAL SCIENCES
    Type: NPO-18667 , NASA Tech Briefs (ISSN 0145-319X); 17; 9; P. 78
    Format: text
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