ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
Filter
  • Male  (5)
  • Mice  (4)
  • Statistical physics  (4)
  • free radicals  (4)
  • 1
    Digitale Medien
    Digitale Medien
    Interrelation of active oxygen species, membrane damage and altered calcium functions (1992)
    Springer
    Molecular and cellular biochemistry 111 (1992), S. 11-15 
    Details
    ISSN: 1573-4919
    Schlagwort(e): superoxide dismutase ; oxidative stress ; toxicology ; calcium fluxes ; free radicals
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract Incubation of freshly isolated rat liver mitochondria in the presence of oxygen free radical generating hypoxanthine —xanthine oxidase system led to swelling of mitochondria as measured by the change in optical density, which was reversed by the addition of superoxide dismutase. O2 − in the presence of CaCl2 enhanced the peroxidative decomposition of mitochondrial membrane lipids along with swelling of the organelle. Free radical generation led to enhancement of monoamine oxidase activity while glutathione peroxidase and cytochrome c oxidase were inhibited. Tertbutyl hydroperoxide (t-BHP) caused mitochondrial swelling through oxidative stress. Incorporation of ruthenium red, which is a Ca2+ transport blocker, during assay abolished peroxidative membrane damage and swelling. Dithiothreitol (DTT) accorded protection against t-BHP induced mitochondrial swelling. The above in vitro data suggest a possible interrelationship of active oxygen species, membrane damage and calcium dynamics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00229568
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 2
    Digitale Medien
    Digitale Medien
    Influence of some biological response modifiers on swelling of rat liver mitochondriain vitro (1993)
    Springer
    Molecular and cellular biochemistry 124 (1993), S. 101-106 
    Details
    ISSN: 1573-4919
    Schlagwort(e): mitochondrial swelling ; lipid peroxidation ; Ca functions ; biological response modifiers ; free radicals
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract In order to understand any involvement of altered calcium functions in peroxidative membrane damage, the effect of a few chemicals, known to modify specific biological responses involving calcium related functions on mitochondrial swellingin vitro was studied. Histamine caused swelling, whereas antihistamines reduced calcium induced swelling. Anti-inflammatory agents aspirin and indomethacin did not affect the initial rapid phase of swelling but reduced the swelling during the later phase. The uncouplers of oxidative phosphorylation and electron transport chain blockers such as dinitrophenol (DNP), antimycin-A and rotenone reduced swelling and the respiratory inhibitors KCN and sodium azide completely abolished it. Trifluoperazine, an anti-calmodulin agent did not influence the initial phase of calcium induced swelling but in the subsequent phase swelling was reduced. c-AMP as well as calcium ionophores, calcimycin and lasalocid acid, potentiated swelling. Thus agents capable of modulating calcium functions could influence thein vitro swelling of mitochondria.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00929201
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 3
    Digitale Medien
    Digitale Medien
    tBHP induced in vitro swelling of rat liver mitochondria (1996)
    Springer
    Molecular and cellular biochemistry 154 (1996), S. 39-45 
    Details
    ISSN: 1573-4919
    Schlagwort(e): free radicals ; oxidative stress ; mitochondrial swelling ; tert-butyl hydroperoxide ; calcium deregulation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract Tert-butyl hydroperoxide induced swelling of freshly isolated rat liver mitochondria was inhibited by butylated hydroxytoluene, butylated hydroxyanisole and α-tocopherol by acting at the initial phase. EDTA was more effective than EGTA in reducing the initial swelling and so were desferal and bipyrridyl. Spermine, an allosteric activator of calcium uptake, enhanced swelling whereas lanthanum and ruthenium red, the Ca2+ uniport blockers, reduced it. Inhibition of phospholipase A2 by dibucaine and Ca2+ activated proteases by antipain and leupeptin also reduced t-BHP induced swelling. The data indicate that peroxidative mitochondrial swelling involves an iron mediated initial rapid phase and a subsequent calcium dependent propagation phase.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00248459
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 4
    Digitale Medien
    Digitale Medien
    Influence of Antioxidants on the Peroxidative Swelling of Mitochondria in vitro (1998)
    Springer
    Cell biology and toxicology 14 (1998), S. 313-321 
    Details
    ISSN: 1573-6822
    Schlagwort(e): antioxidants ; free radicals ; oxidative swelling ; peroxidation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract To clarify the role of prooxidative processes during in vitro swelling of freshly isolated rat liver mitochondria, the influence of different antioxidants and free-radical scavengers was tested. Ascorbate below 10 mmol/L without externally added Fe2+ acted as a prooxidant and enhanced swelling. Higher concentrations in the presence of Fe2+ showed antioxidant properties and a decrease in swelling and lipid peroxidation. Swelling was abolished by α-tocopherol and reduced to 50% by butylated hydroxytoluene. Glutathione supplementation decreased both swelling and lipid peroxidation. Oxidized glutathione caused swelling without any effect on peroxidation. Hydrogen peroxide, cumene hydroperoxide and t-butyl hydroperoxide caused progressive decreases in glutathione and reduced niacinamide coenzyme levels, suggesting prooxidative changes. Dithiothreitol was found to abolish this effect. Thus, antioxidants reverse superoxide-induced mito chondrial swelling and lipid peroxidation in vitro.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1007529622874
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 5
    facet.materialart.
    Unbekannt
    Alzheimer random walk model: Two previously overlooked diffusion regimes (2012)
    American Physical Society (APS)
    Details
    Publikationsdatum: 2012-10-03
    Beschreibung: Author(s): J. C. Cressoni, G. M. Viswanathan, A. S. Ferreira, and M. A. A. da Silva A non-Markovian one-dimensional random walk model is studied with emphasis on the phase-diagram, showing all the diffusion regimes, along with the exactly determined critical lines. The model, known as the Alzheimer walk, is endowed with memory-controlled diffusion, responsible for the model's long-... [Phys. Rev. E 86, 042101] Published Tue Oct 02, 2012
    Schlagwort(e): Statistical physics
    Print ISSN: 1539-3755
    Digitale ISSN: 1550-2376
    Thema: Physik
    Publiziert von American Physical Society (APS)
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    AKTUELLE ARTIKEL
  • 6
    facet.materialart.
    Unbekannt
    Conditions under which a superdiffusive random-search strategy is necessary (2012)
    American Physical Society (APS)
    Details
    Publikationsdatum: 2012-09-25
    Beschreibung: Author(s): S. A. Sotelo-López, M. C. Santos, E. P. Raposo, G. M. Viswanathan, and M. G. E. da Luz Intuitively, lower target densities and lower detection capabilities should demand more sophisticated search strategies for a random search reasonable outcome. In contrast, when targets are easily found, a simple Brownian random walk strategy is enough. But where is the threshold between these two s... [Phys. Rev. E 86, 031133] Published Mon Sep 24, 2012
    Schlagwort(e): Statistical physics
    Print ISSN: 1539-3755
    Digitale ISSN: 1550-2376
    Thema: Physik
    Publiziert von American Physical Society (APS)
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    AKTUELLE ARTIKEL
  • 7
    facet.materialart.
    Unbekannt
    Dissipative Lévy random searches: Universal behavior at low target density (2012)
    American Physical Society (APS)
    Details
    Publikationsdatum: 2012-12-05
    Beschreibung: Author(s): P. J. Ribeiro-Neto, E. P. Raposo, H. A. Araújo, C. L. Faustino, M. G. E. da Luz, and G. M. Viswanathan We investigate the problem of survival at the very low target-density limit and report on a second-order phase transition for one-dimensional random searches in which the energy cost of locomotion is a function of the distance traveled by the searcher. Surprisingly, from analytical calculations (als... [Phys. Rev. E 86, 061102] Published Tue Dec 04, 2012
    Schlagwort(e): Statistical physics
    Print ISSN: 1539-3755
    Digitale ISSN: 1550-2376
    Thema: Physik
    Publiziert von American Physical Society (APS)
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    AKTUELLE ARTIKEL
  • 8
    facet.materialart.
    Unbekannt
    Weakly anomalous diffusion with non-Gaussian propagators (2012)
    American Physical Society (APS)
    Details
    Publikationsdatum: 2012-08-28
    Beschreibung: Author(s): J. C. Cressoni, G. M. Viswanathan, A. S. Ferreira, and M. A. A. da Silva A poorly understood phenomenon seen in complex systems is diffusion characterized by Hurst exponent H ≈1/2 but with non-Gaussian statistics. Motivated by such empirical findings, we report an exact analytical solution for a non-Markovian random walk model that gives rise to weakly anomalous diffusion... [Phys. Rev. E 86, 022103] Published Mon Aug 27, 2012
    Schlagwort(e): Statistical physics
    Print ISSN: 1539-3755
    Digitale ISSN: 1550-2376
    Thema: Physik
    Publiziert von American Physical Society (APS)
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    AKTUELLE ARTIKEL
  • 9
    facet.materialart.
    Unbekannt
    A role for Lin28 in primordial germ-cell development and germ-cell malignancy (2009)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2009-07-07
    Beschreibung: The rarity and inaccessibility of the earliest primordial germ cells (PGCs) in the mouse embryo thwart efforts to investigate molecular mechanisms of germ-cell specification. stella (also called Dppa3) marks the rare founder population of the germ lineage. Here we differentiate mouse embryonic stem cells carrying a stella transgenic reporter into putative PGCs in vitro. The Stella(+) cells possess a transcriptional profile similar to embryo-derived PGCs, and like their counterparts in vivo, lose imprints in a time-dependent manner. Using inhibitory RNAs to screen candidate genes for effects on the development of Stella(+) cells in vitro, we discovered that Lin28, a negative regulator of let-7 microRNA processing, is essential for proper PGC development. Furthermore, we show that Blimp1 (also called Prdm1), a let-7 target and a master regulator of PGC specification, can rescue the effect of Lin28 deficiency during PGC development, thereby establishing a mechanism of action for Lin28 during PGC specification. Overexpression of Lin28 promotes formation of Stella(+) cells in vitro and PGCs in chimaeric embryos, and is associated with human germ-cell tumours. The differentiation of putative PGCs from embryonic stem cells in vitro recapitulates the early stages of gamete development in vivo, and provides an accessible system for discovering novel genes involved in germ-cell development and malignancy.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729657/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729657/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉West, Jason A -- Viswanathan, Srinivas R -- Yabuuchi, Akiko -- Cunniff, Kerianne -- Takeuchi, Ayumu -- Park, In-Hyun -- Sero, Julia E -- Zhu, Hao -- Perez-Atayde, Antonio -- Frazier, A Lindsay -- Surani, M Azim -- Daley, George Q -- DP1 OD000256/OD/NIH HHS/ -- DP1 OD000256-01/OD/NIH HHS/ -- G0300723/Medical Research Council/United Kingdom -- G0800784/Medical Research Council/United Kingdom -- T32 CA009172/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2009 Aug 13;460(7257):909-13. doi: 10.1038/nature08210. Epub 2009 Jul 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Pediatric Hematology/Oncology, Children's Hospital Boston and the Dana-Farber Cancer Institute, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19578360" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Cell Differentiation ; Cell Line ; Embryonic Stem Cells/cytology/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Germ Cells/*cytology/*metabolism/pathology ; Humans ; Mice ; Mice, Inbred C57BL ; Neoplasms, Germ Cell and Embryonal/genetics/*metabolism/*pathology ; RNA-Binding Proteins/genetics/*metabolism ; Repressor Proteins/genetics/metabolism ; Transcription Factors/metabolism ; Transgenes
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Nature Publishing Group (NPG)
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    AKTUELLE ARTIKEL
  • 10
    facet.materialart.
    Unbekannt
    Hemagglutinin receptor binding avidity drives influenza A virus antigenic drift (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2009-11-11
    Beschreibung: Rapid antigenic evolution in the influenza A virus hemagglutinin precludes effective vaccination with existing vaccines. To understand this phenomenon, we passaged virus in mice immunized with influenza vaccine. Neutralizing antibodies selected mutants with single-amino acid hemagglutinin substitutions that increased virus binding to cell surface glycan receptors. Passaging these high-avidity binding mutants in naive mice, but not immune mice, selected for additional hemagglutinin substitutions that decreased cellular receptor binding avidity. Analyzing a panel of monoclonal antibody hemagglutinin escape mutants revealed a positive correlation between receptor binding avidity and escape from polyclonal antibodies. We propose that in response to variation in neutralizing antibody pressure between individuals, influenza A virus evolves by adjusting receptor binding avidity via amino acid substitutions throughout the hemagglutinin globular domain, many of which simultaneously alter antigenicity.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784927/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784927/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hensley, Scott E -- Das, Suman R -- Bailey, Adam L -- Schmidt, Loren M -- Hickman, Heather D -- Jayaraman, Akila -- Viswanathan, Karthik -- Raman, Rahul -- Sasisekharan, Ram -- Bennink, Jack R -- Yewdell, Jonathan W -- GM 57073/GM/NIGMS NIH HHS/ -- U54 GM62116/GM/NIGMS NIH HHS/ -- Z01 AI001014-01/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2009 Oct 30;326(5953):734-6. doi: 10.1126/science.1178258.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19900932" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Antigenic Variation/genetics/*immunology ; Cell Line ; Hemagglutinin Glycoproteins, Influenza Virus/genetics/immunology/*metabolism ; Influenza A Virus, H1N1 Subtype/genetics/*immunology ; Influenza Vaccines/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Models, Immunological ; Mutation ; Receptors, Virus/*metabolism ; Serial Passage
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    AKTUELLE ARTIKEL
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...