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Role of Ca2+ ion on Leishmania-macrophage attachment (1991)

Misra, Sujata ; Naskar, Kshudiram ; Sarkar, Dwijen ; [et al.]

Springer

Molecular and cellular biochemistry 102 (1991), S. 13-18

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ISSN: 1573-4919

Keywords: Ca2+-channel blocker ; verapamil ; macrophage ; nifedipine ; Leishmania donovani ; calcium ionophore

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology , Medicine

Notes: Summary Leishmania donovani, the etiological agent for the disease visceral leishmaniasis, attach themselves to the macrophages for initiation of the disease. The attachment process has been found to be regulated by Ca2+ ions. Verapamil, a Ca2+-channel blocker inhibits Leishmania-macrophage attachment. The inhibitory effect is increased with time. Nifedipine, another Ca2+-channel blocker exhibits the same effect. The attachment process is stimulated by Ca2+-ionophore alone. The inhibitory effects of the calcium channel blockers are reversed by the ionophore.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00232154

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