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Role of Ca2+ ion on Leishmania-macrophage attachment

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Summary

Leishmania donovani, the etiological agent for the disease visceral leishmaniasis, attach themselves to the macrophages for initiation of the disease. The attachment process has been found to be regulated by Ca2+ ions. Verapamil, a Ca2+-channel blocker inhibits Leishmania-macrophage attachment. The inhibitory effect is increased with time. Nifedipine, another Ca2+-channel blocker exhibits the same effect. The attachment process is stimulated by Ca2+-ionophore alone. The inhibitory effects of the calcium channel blockers are reversed by the ionophore.

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Authors and Affiliations

  1. Leishmania Group, Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, 700 032, Calcutta, India

    Sujata Misra, Kshudiram Naskar, Dwijen Sarkar & Dilip Kumar Ghosh

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  1. Sujata Misra
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  2. Kshudiram Naskar
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  3. Dwijen Sarkar
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  4. Dilip Kumar Ghosh
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Misra, S., Naskar, K., Sarkar, D. et al. Role of Ca2+ ion on Leishmania-macrophage attachment. Mol Cell Biochem 102, 13–18 (1991). https://doi.org/10.1007/BF00232154

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  • DOI: https://doi.org/10.1007/BF00232154

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