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  • 1
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    Central hypotensive effects of the alpha2a-adrenergic receptor subtype (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-08-09
    Description: alpha2-Adrenergic receptors (alpha2ARs) present in the brainstem decrease blood pressure and are targets for clinically effective antihypertensive drugs. The existence of three alpha2AR subtypes, the lack of subtype-specific ligands, and the cross-reactivity of alpha2AR agonists with imidazoline receptors has precluded an understanding of the role of individual alpha2AR subtypes in the hypotensive response. Gene targeting was used to introduce a point mutation into the alpha2aAR subtype in the mouse genome. The hypotensive response to alpha2AR agonists was lost in the mutant mice, demonstrating that the alpha2aAR subtype plays a principal role in this response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacMillan, L B -- Hein, L -- Smith, M S -- Piascik, M T -- Limbird, L E -- HL38120/HL/NHLBI NIH HHS/ -- HL43671/HL/NHLBI NIH HHS/ -- HL48638/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1996 Aug 9;273(5276):801-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8670421" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic alpha-2 Receptor Agonists ; Adrenergic alpha-Agonists/pharmacology ; Animals ; Antihypertensive Agents/pharmacology ; Base Sequence ; Blood Pressure/drug effects/*physiology ; Brain Stem/physiology ; Brimonidine Tartrate ; Gene Targeting ; Heart Rate/drug effects/physiology ; Imidazoles/pharmacology ; Medetomidine ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Point Mutation ; Quinoxalines/pharmacology ; Receptors, Adrenergic, alpha-2/genetics/metabolism/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
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    Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-08-09
    Description: alpha2-Adrenergic receptors (alpha2ARs) are essential components of the neural circuitry regulating cardiovascular function. The role of specific alpha2AR subtypes (alpha2a, alpha2b, and alpha2c) was characterized with hemodynamic measurements obtained from strains of genetically engineered mice deficient in either alpha2b or alpha2c receptors. Stimulation of alpha2b receptors in vascular smooth muscle produced hypertension and counteracted the clinically beneficial hypotensive effect of stimulating alpha2a receptors in the central nervous system. There were no hemodynamic effects produced by disruption of the alpha2c subtype. These results provide evidence for the clinical efficacy of more subtype-selective alpha2AR drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Link, R E -- Desai, K -- Hein, L -- Stevens, M E -- Chruscinski, A -- Bernstein, D -- Barsh, G S -- Kobilka, B K -- GM07365/GM/NIGMS NIH HHS/ -- HL48638/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1996 Aug 9;273(5276):803-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8670422" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic alpha-Agonists/pharmacology ; Adrenergic alpha-Antagonists/metabolism/pharmacology ; Animals ; Blood Pressure/drug effects/*physiology ; Gene Targeting ; Heart Rate/drug effects/*physiology ; Imidazoles/pharmacology ; Kidney/metabolism ; Medetomidine ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Mice, Knockout ; Muscle, Smooth, Vascular/metabolism ; Phenylephrine/pharmacology ; Prazosin/pharmacology ; Receptors, Adrenergic, alpha-2/genetics/*physiology ; Yohimbine/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Resilient seal ring assembly with spring means applying force to wedge member (1983)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: A ring seal adapted for installation in an annular recess between a housing and a rotating or reciprocating shaft is described. The seal consists of a resilient ring cup member having a ring wedge member inserted in the center recess of the cup member to wedge the opposing lips of the cup member outwardly into a sealing relationship. A spring maintains the force against the wedge member.
    Keywords: MECHANICAL ENGINEERING
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 4
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    Spherical bearing (1978)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: A spherical bearing including an inner ball with an opening for receiving a shaft and a spherical outer surface is described. Features of the bearing include: (1) a circular outer race including a plurality of circumferentially spaced sections extending around the inner ball for snugly receiving the inner ball; and (2) a groove extending circumferentially around the race producing a thin wall portion which permits the opposed side portions to flex relative to the ball for maximizing the physical contact between the inner surface of the race and the spherical outer surface of the ball.
    Keywords: MECHANICAL ENGINEERING
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    NASA TECHNICAL REPORTS
  • 5
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    Mechanical thermal motor (1976)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: An apparatus is described for converting thermal energy such as solar energy into mechanical motion for driving fluid pumps and similar equipment. The thermal motor comprises an inner concentric cylinder carried by a stationary core member. The core member has a cylindrical disc plate fixed adjacent to a lower portion and extending radially from it. An outer concentric cylinder rotatably carried on the disc plate defining a space between the inner and outer concentric cylinders. A spiral tubular member encircles the inner concentric cylinder and is contained within the space between the inner and outer cylinders. One portion is connected to the inner concentric cylinder and a second portion connected to the outer concentric cylinder. A heated fluid is conveyed through the tubular member and is periodically cooled causing the tubular member to expand and contract. This causes the outer concentric cylinder to reciprocally rotate on the base plate accordingly. The reciprocating motion of the outer concentric cylinder is then utilized to drive a pump member in a pump chamber.
    Keywords: MECHANICAL ENGINEERING
    Format: application/pdf
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    NASA TECHNICAL REPORTS
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