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  • 1
    Publication Date: 2005-10-29
    Description: Global change will alter the supply of ecosystem services that are vital for human well-being. To investigate ecosystem service supply during the 21st century, we used a range of ecosystem models and scenarios of climate and land-use change to conduct a Europe-wide assessment. Large changes in climate and land use typically resulted in large changes in ecosystem service supply. Some of these trends may be positive (for example, increases in forest area and productivity) or offer opportunities (for example, "surplus land" for agricultural extensification and bioenergy production). However, many changes increase vulnerability as a result of a decreasing supply of ecosystem services (for example, declining soil fertility, declining water availability, increasing risk of forest fires), especially in the Mediterranean and mountain regions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schroter, Dagmar -- Cramer, Wolfgang -- Leemans, Rik -- Prentice, I Colin -- Araujo, Miguel B -- Arnell, Nigel W -- Bondeau, Alberte -- Bugmann, Harald -- Carter, Timothy R -- Gracia, Carlos A -- de la Vega-Leinert, Anne C -- Erhard, Markus -- Ewert, Frank -- Glendining, Margaret -- House, Joanna I -- Kankaanpaa, Susanna -- Klein, Richard J T -- Lavorel, Sandra -- Lindner, Marcus -- Metzger, Marc J -- Meyer, Jeannette -- Mitchell, Timothy D -- Reginster, Isabelle -- Rounsevell, Mark -- Sabate, Santi -- Sitch, Stephen -- Smith, Ben -- Smith, Jo -- Smith, Pete -- Sykes, Martin T -- Thonicke, Kirsten -- Thuiller, Wilfried -- Tuck, Gill -- Zaehle, Sonke -- Zierl, Barbel -- New York, N.Y. -- Science. 2005 Nov 25;310(5752):1333-7. Epub 2005 Oct 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Potsdam Institute for Climate Impact Research, 14473 Potsdam, Germany. dagmar.schroeter@gmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16254151" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Biodiversity ; Carbon ; Climate ; Conservation of Natural Resources ; Crops, Agricultural ; *Ecosystem ; Environment ; Europe ; Greenhouse Effect ; Humans ; Models, Statistical ; Models, Theoretical ; Socioeconomic Factors ; Trees/growth & development ; Urban Population ; Water Supply ; Wood
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2005-03-12
    Description: Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. We report a genome-wide screen of 96 cases and 50 controls for polymorphisms associated with AMD. Among 116,204 single-nucleotide polymorphisms genotyped, an intronic and common variant in the complement factor H gene (CFH) is strongly associated with AMD (nominal P value 〈10(-7)). In individuals homozygous for the risk allele, the likelihood of AMD is increased by a factor of 7.4 (95% confidence interval 2.9 to 19). Resequencing revealed a polymorphism in linkage disequilibrium with the risk allele representing a tyrosine-histidine change at amino acid 402. This polymorphism is in a region of CFH that binds heparin and C-reactive protein. The CFH gene is located on chromosome 1 in a region repeatedly linked to AMD in family-based studies.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1512523/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1512523/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klein, Robert J -- Zeiss, Caroline -- Chew, Emily Y -- Tsai, Jen-Yue -- Sackler, Richard S -- Haynes, Chad -- Henning, Alice K -- SanGiovanni, John Paul -- Mane, Shrikant M -- Mayne, Susan T -- Bracken, Michael B -- Ferris, Frederick L -- Ott, Jurg -- Barnstable, Colin -- Hoh, Josephine -- K01RR16090/RR/NCRR NIH HHS/ -- K25HG000060/HG/NHGRI NIH HHS/ -- R01EY015771/EY/NEI NIH HHS/ -- R01MH44292/MH/NIMH NIH HHS/ -- Z99 EY999999/Intramural NIH HHS/ -- ZIA EY000489-01/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2005 Apr 15;308(5720):385-9. Epub 2005 Mar 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15761122" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Aged, 80 and over ; Aging ; Alleles ; Amino Acid Substitution ; Case-Control Studies ; Choroid/immunology ; Chromosomes, Human, Pair 1/genetics ; Complement Factor H/chemistry/*genetics/physiology ; Complement Membrane Attack Complex/analysis ; Exons ; Female ; Genetic Markers ; Genetic Predisposition to Disease ; Genotype ; Haplotypes ; Histidine/genetics ; Humans ; Immunity, Innate ; Introns ; Linkage Disequilibrium ; Macular Degeneration/*genetics ; Male ; Oligonucleotide Array Sequence Analysis ; Pigment Epithelium of Eye/immunology ; Polymorphism, Genetic ; *Polymorphism, Single Nucleotide ; Risk Factors ; Smoking
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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