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    The centromere paradox: stable inheritance with rapidly evolving DNA (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-08-11
    Description: Every eukaryotic chromosome has a centromere, the locus responsible for poleward movement at mitosis and meiosis. Although conventional loci are specified by their DNA sequences, current evidence favors a chromatin-based inheritance mechanism for centromeres. The chromosome segregation machinery is highly conserved across all eukaryotes, but the DNA and protein components specific to centromeric chromatin are evolving rapidly. Incompatibilities between rapidly evolving centromeric components may be responsible for both the organization of centromeric regions and the reproductive isolation of emerging species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Henikoff, S -- Ahmad, K -- Malik, H S -- New York, N.Y. -- Science. 2001 Aug 10;293(5532):1098-102.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute Research Laboratories, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11498581" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Centromere/*genetics/physiology ; Chromatin/physiology ; Chromosomal Proteins, Non-Histone/chemistry/*metabolism ; *DNA, Satellite/chemistry/genetics/metabolism ; *Evolution, Molecular ; Female ; Histones/chemistry/*metabolism ; Humans ; Male ; Meiosis ; Models, Genetic ; Nucleosomes/physiology ; Repetitive Sequences, Nucleic Acid
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Altered heterochromatin binding by a hybrid sterility protein in Drosophila sibling species (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-11-26
    Description: Hybrid sterility of the heterogametic sex is one of the first postzygotic reproductive barriers to evolve during speciation, yet the molecular basis of hybrid sterility is poorly understood. We show that the hybrid male sterility gene Odysseus-site homeobox (OdsH) encodes a protein that localizes to evolutionarily dynamic loci within heterochromatin and leads to their decondensation. In Drosophila mauritiana x Drosophila simulans male hybrids, OdsH from D. mauritiana (OdsHmau) acts as a sterilizing factor by associating with the heterochromatic Y chromosome of D. simulans, whereas D. simulans OdsH (OdsHsim) does not. Characterization of sterile hybrid testes revealed that OdsH abundance and localization in the premeiotic phases of spermatogenesis differ between species. These results reveal that rapid heterochromatin evolution affects the onset of hybrid sterility.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987944/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987944/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bayes, Joshua J -- Malik, Harmit S -- R01 GM074108/GM/NIGMS NIH HHS/ -- R01 GM074108-05/GM/NIGMS NIH HHS/ -- R01-GM74108/GM/NIGMS NIH HHS/ -- T32 GM07270/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2009 Dec 11;326(5959):1538-41. doi: 10.1126/science.1181756. Epub .〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98185, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19933102" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Genetically Modified ; Chromosomes/metabolism/physiology ; Crosses, Genetic ; DNA, Satellite/*metabolism ; Drosophila/genetics/*physiology ; Drosophila Proteins/genetics/*metabolism ; Female ; Fertility ; G2 Phase ; Genetic Speciation ; Heterochromatin/*metabolism ; Homeodomain Proteins/genetics/*metabolism ; Hybridization, Genetic ; Male ; Meiosis ; Recombinant Fusion Proteins/metabolism ; Spermatocytes/cytology/metabolism ; Spermatogenesis ; Testis/metabolism ; X Chromosome/metabolism ; Y Chromosome/*metabolism/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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