Publication Date:
1984-02-10
Description:
Rats under Pavlovian defensive conditioning (noise paired with shock) while under general anesthesia. Peripheral administration of epinephrine (0.01 to 1.0 milligram per kilogram of body weight) during training resulted in the acquisition of conditioned fear, as shown 10 days later by conditioned suppression of water drinking. Analysis of heart rate and measurement of reflexes during training indicated that epinephrine did not lighten the state of anesthesia. These results indicate that epinephrine enables the learning of conditioned fear in the anesthetized brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weinberger, N M -- Gold, P E -- Sternberg, D B -- AL 01642/PHS HHS/ -- MH 12526/MH/NIMH NIH HHS/ -- MH 31144/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1984 Feb 10;223(4636):605-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695173" target="_blank"〉PubMed〈/a〉
Keywords:
*Anesthesia, General
;
Animals
;
Chloral Hydrate
;
Conditioning (Psychology)/*drug effects
;
Epinephrine/*pharmacology
;
Fear
;
Male
;
Pentobarbital
;
Rats
;
Rats, Inbred Strains
;
*Reinforcement (Psychology)
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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