Publication Date:
2001-08-11
Description:
Every eukaryotic chromosome has a centromere, the locus responsible for poleward movement at mitosis and meiosis. Although conventional loci are specified by their DNA sequences, current evidence favors a chromatin-based inheritance mechanism for centromeres. The chromosome segregation machinery is highly conserved across all eukaryotes, but the DNA and protein components specific to centromeric chromatin are evolving rapidly. Incompatibilities between rapidly evolving centromeric components may be responsible for both the organization of centromeric regions and the reproductive isolation of emerging species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Henikoff, S -- Ahmad, K -- Malik, H S -- New York, N.Y. -- Science. 2001 Aug 10;293(5532):1098-102.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute Research Laboratories, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11498581" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Centromere/*genetics/physiology
;
Chromatin/physiology
;
Chromosomal Proteins, Non-Histone/chemistry/*metabolism
;
*DNA, Satellite/chemistry/genetics/metabolism
;
*Evolution, Molecular
;
Female
;
Histones/chemistry/*metabolism
;
Humans
;
Male
;
Meiosis
;
Models, Genetic
;
Nucleosomes/physiology
;
Repetitive Sequences, Nucleic Acid
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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