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  • Electronic structure and strongly correlated systems  (3)
  • Transcription, Genetic  (2)
  • 1
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    Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-07-31
    Description: Protein and messenger RNA (mRNA) copy numbers vary from cell to cell in isogenic bacterial populations. However, these molecules often exist in low copy numbers and are difficult to detect in single cells. We carried out quantitative system-wide analyses of protein and mRNA expression in individual cells with single-molecule sensitivity using a newly constructed yellow fluorescent protein fusion library for Escherichia coli. We found that almost all protein number distributions can be described by the gamma distribution with two fitting parameters which, at low expression levels, have clear physical interpretations as the transcription rate and protein burst size. At high expression levels, the distributions are dominated by extrinsic noise. We found that a single cell's protein and mRNA copy numbers for any given gene are uncorrelated.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922915/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922915/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taniguchi, Yuichi -- Choi, Paul J -- Li, Gene-Wei -- Chen, Huiyi -- Babu, Mohan -- Hearn, Jeremy -- Emili, Andrew -- Xie, X Sunney -- DP1 OD000277/OD/NIH HHS/ -- DP1 OD000277-03/OD/NIH HHS/ -- DP1 OD000277-04/OD/NIH HHS/ -- DP1 OD000277-05/OD/NIH HHS/ -- MOP-77639/Canadian Institutes of Health Research/Canada -- New York, N.Y. -- Science. 2010 Jul 30;329(5991):533-8. doi: 10.1126/science.1188308.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20671182" target="_blank"〉PubMed〈/a〉
    Keywords: Escherichia coli/chemistry/*genetics/metabolism ; Escherichia coli Proteins/*analysis/metabolism ; *Gene Expression ; *Gene Expression Profiling ; Gene Library ; In Situ Hybridization, Fluorescence ; Luminescent Proteins ; Microfluidic Analytical Techniques ; Microscopy, Fluorescence ; Protein Biosynthesis ; Proteome/*analysis ; RNA Stability ; RNA, Bacterial/analysis/genetics/metabolism ; RNA, Messenger/*analysis/genetics ; Saccharomyces cerevisiae/chemistry/genetics/metabolism ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-05-19
    Description: Copy number variants (CNVs) are major contributors to genetic disorders. We have dissected a region of the 16p11.2 chromosome--which encompasses 29 genes--that confers susceptibility to neurocognitive defects when deleted or duplicated. Overexpression of each human transcript in zebrafish embryos identified KCTD13 as the sole message capable of inducing the microcephaly phenotype associated with the 16p11.2 duplication, whereas suppression of the same locus yielded the macrocephalic phenotype associated with the 16p11.2 deletion, capturing the mirror phenotypes of humans. Analyses of zebrafish and mouse embryos suggest that microcephaly is caused by decreased proliferation of neuronal progenitors with concomitant increase in apoptosis in the developing brain, whereas macrocephaly arises by increased proliferation and no changes in apoptosis. A role for KCTD13 dosage changes is consistent with autism in both a recently reported family with a reduced 16p11.2 deletion and a subject reported here with a complex 16p11.2 rearrangement involving de novo structural alteration of KCTD13. Our data suggest that KCTD13 is a major driver for the neurodevelopmental phenotypes associated with the 16p11.2 CNV, reinforce the idea that one or a small number of transcripts within a CNV can underpin clinical phenotypes, and offer an efficient route to identifying dosage-sensitive loci.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366115/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366115/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Golzio, Christelle -- Willer, Jason -- Talkowski, Michael E -- Oh, Edwin C -- Taniguchi, Yu -- Jacquemont, Sebastien -- Reymond, Alexandre -- Sun, Mei -- Sawa, Akira -- Gusella, James F -- Kamiya, Atsushi -- Beckmann, Jacques S -- Katsanis, Nicholas -- F32MH087123/MH/NIMH NIH HHS/ -- HD06286/HD/NICHD NIH HHS/ -- MH-084018/MH/NIMH NIH HHS/ -- MH-091230/MH/NIMH NIH HHS/ -- P50 MH094268/MH/NIMH NIH HHS/ -- P50 MH094268-02/MH/NIMH NIH HHS/ -- R01 MH091230/MH/NIMH NIH HHS/ -- R01 MH092443/MH/NIMH NIH HHS/ -- England -- Nature. 2012 May 16;485(7398):363-7. doi: 10.1038/nature11091.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Human Disease Modeling and Department of Cell biology, Duke University, Durham, North Carolina 27710, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22596160" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis/genetics ; Cell Proliferation ; Chromosomes, Human, Pair 16/*genetics ; DNA Copy Number Variations/*genetics ; Gene Dosage/*genetics ; Gene Duplication/genetics ; Head/*abnormalities/embryology ; Humans ; Mice ; Microcephaly/*genetics ; Nuclear Proteins/*genetics/metabolism ; Organ Size/genetics ; *Phenotype ; RNA, Messenger/genetics/metabolism ; Sequence Deletion/genetics ; Transcription, Genetic ; Up-Regulation ; Zebrafish/abnormalities/embryology/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    Emergence of charge degrees of freedom under high pressure in the organic dimer-Mott insulator β^{′} −(BEDT−TTF)_{2} ICl_{2} (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-08-29
    Description: Author(s): K. Hashimoto, R. Kobayashi, H. Okamura, H. Taniguchi, Y. Ikemoto, T. Moriwaki, S. Iguchi, M. Naka, S. Ishihara, and T. Sasaki To elucidate the pressure evolution of the electronic structure in an antiferromagnetic dimer-Mott (DM) insulator β ′ − ( BEDT − TTF ) 2 ICl 2 , which exhibits superconductivity at 14.2 K under 8 GPa, we measured the polarized infrared (IR) optical spectra under high pressure. At ambient pressure, two characte… [Phys. Rev. B 92, 085149] Published Fri Aug 28, 2015
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 4
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    Electronic structure of a narrow-gap semiconductor FeGa_{3} investigated by photoemission and inverse photoemission spectroscopies (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-06-23
    Description: Author(s): M. Arita, K. Shimada, Y. Utsumi, O. Morimoto, H. Sato, H. Namatame, M. Taniguchi, Y. Hadano, and T. Takabatake We have performed a photoemission and inverse photoemission spectroscopic study of a narrow-gap semiconductor FeGa 3 , in order to characterize the occupied and unoccupied electronic states. The energy-gap size was found to be ~0.4  eV, and the valence-band maximum (VBM) was located around the A point ... [Phys. Rev. B 83, 245116] Published Wed Jun 22, 2011
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 5
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    Spectroscopic signature of trimer Mott insulator and charge disproportionation in ${\mathrm{BaIrO}}_{3}$ (2018)
    American Physical Society (APS)
    Details
    Publication Date: 2018-11-17
    Description: Author(s): R. Okazaki, S. Ito, K. Tanabe, H. Taniguchi, Y. Ikemoto, T. Moriwaki, and I. Terasaki We have measured the reflectivity spectra of the barium iridate 9 R BaIrO 3 , the crystal structure of which consists of characteristic Ir 3 O 12 trimers. In the high-temperature phase above the transition temperature T c ≃ 180  K, we find that the optical conductivity involves two temperature-dependent optica... [Phys. Rev. B 98, 205131] Published Fri Nov 16, 2018
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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