Publication Date:
1999-10-03
Description:
In a direct approach to elucidate the origin of long-term depression (LTD), glutamate was applied onto dendrites of neurons in rat neocortical slices. An infrared-guided laser stimulation was used to release glutamate from caged glutamate in the focal spot of an ultraviolet laser. A burst of light flashes caused an LTD-like depression of glutamate receptor responses, which was highly confined to the region of "tetanic" stimulation (〈10 micrometers). A similar depression of glutamate receptor responses was observed during LTD of synaptic transmission. A spatially highly specific postsynaptic mechanism can account for the LTD induced by glutamate release.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dodt, H -- Eder, M -- Frick, A -- Zieglgansberger, W -- New York, N.Y. -- Science. 1999 Oct 1;286(5437):110-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max-Planck-Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany. dodt@mpipsykl.mpg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10506556" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Dizocilpine Maleate/pharmacology
;
Electric Stimulation
;
Excitatory Amino Acid Antagonists/pharmacology
;
Excitatory Postsynaptic Potentials
;
Glutamates/pharmacology
;
Glutamic Acid/metabolism
;
In Vitro Techniques
;
Infrared Rays
;
Lasers
;
Microscopy, Video
;
Neocortex/cytology/*physiology
;
*Neuronal Plasticity
;
Patch-Clamp Techniques
;
Photolysis
;
Pyramidal Cells/*physiology
;
Rats
;
Rats, Sprague-Dawley
;
Receptors, Glutamate/*metabolism
;
Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/metabolism
;
Synapses/*physiology
;
*Synaptic Transmission
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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