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  • 1
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    Effects of the obese gene product on body weight regulation in ob/ob mice (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-07-28
    Description: C57BL/6J mice with a mutation in the obese (ob) gene are obese, diabetic, and exhibit reduced activity, metabolism, and body temperature. Daily intraperitoneal injection of these mice with recombinant OB protein lowered their body weight, percent body fat, food intake, and serum concentrations of glucose and insulin. In addition, metabolic rate, body temperature, and activity levels were increased by this treatment. None of these parameters was altered beyond the level observed in lean controls, suggesting that the OB protein normalized the metabolic status of the ob/ob mice. Lean animals injected with OB protein maintained a smaller weight loss throughout the 28-day study and showed no changes in any of the metabolic parameters. These data suggest that the OB protein regulates body weight and fat deposition through effects on metabolism and appetite.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pelleymounter, M A -- Cullen, M J -- Baker, M B -- Hecht, R -- Winters, D -- Boone, T -- Collins, F -- New York, N.Y. -- Science. 1995 Jul 28;269(5223):540-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Amgen, Inc., Thousand Oaks, CA 91320, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7624776" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue/drug effects ; Analysis of Variance ; Animals ; Blood Glucose/analysis ; Body Composition/drug effects ; Body Temperature/drug effects ; Dose-Response Relationship, Drug ; Drinking/drug effects ; Eating/*drug effects ; Energy Metabolism/drug effects ; Female ; Insulin/blood ; Leptin ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Motor Activity/drug effects ; Obesity/genetics/*physiopathology ; Oxygen Consumption/drug effects ; Proteins/genetics/*pharmacology ; Recombinant Proteins/pharmacology ; Weight Loss/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
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    Simultaneous satellite and riometer studies (1974)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: The expected 30 and 50 MHz riometer absorption was calculated for the 7 June, 25 September and 2 November 1969 solar events using data from the McDonnell Douglas charged particle experiment on the polar orbiting OGO-6 Satellite. Excellent agreement was found between measured polar cap riometer absorption during the events and absorption calculated from detailed particle data obtained on the satellite passing over the riometer. Electrons are found to contribute the greater part of the 30 MHz absorption before the peak of the 2 November 1969 event; at all other times protons produce most of the absorption. The alpha-particle contribution is negligible in all cases.
    Keywords: SPACE RADIATION
    Type: NSSDC-ID-69-051A-19-PM , International Cosmic Ray Conference; Aug 17, 1973 - Aug 30, 1973; Denver, CO
    Format: text
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    NASA TECHNICAL REPORTS
  • 3
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    Simultaneous satellite and riometer measurements of particles during solar cosmic ray events. (1972)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: The expected 30 and 50 MHz riometer absorptions have been calculated for three events in 1969 using data from the MDAC-W charged particle experiment on OGO 6. Several times during each event, the satellite passed over the MDAC-W Arctic and Antarctic Geophysical Observatories. The calculated total absorption (using 2 minute averages of the data) agrees well with the measured absorption for the overpasses. The alpha particle and electron contributions usually amount to less than a few percent of the proton absorption. During the large November 2, 1969 event, however, the electrons produced the major part of the absorption up to the peak and a significant contribution during virtually its entire duration. With the two frequencies for which simultaneous riometer data were taken, it is possible to detect the softening of the particle spectra during the events, and the relative hardness differences between events.
    Keywords: SPACE RADIATION
    Type: NSSDC-ID-69-051A-19-PM , COSPAR, Plenary Meeting; May 10, 1972 - May 24, 1972; Madrid; Spain
    Format: text
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    NASA TECHNICAL REPORTS
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