Publication Date:
2007-01-27
Description:
In the developing fly wing, secreted morphogens such as Decapentaplegic (Dpp) and Wingless (Wg) form gradients of concentration providing positional information. Dpp forms a longer-range gradient than Wg. To understand how the range is controlled, we measured the four key kinetic parameters governing morphogen spreading: the production rate, the effective diffusion coefficient, the degradation rate, and the immobile fraction. The four parameters had different values for Dpp versus Wg. In addition, Dynamin-dependent endocytosis was required for spreading of Dpp, but not Wg. Thus, the cellular mechanisms of Dpp and Wingless spreading are different: Dpp spreading requires endocytic, intracellular trafficking.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kicheva, Anna -- Pantazis, Periklis -- Bollenbach, Tobias -- Kalaidzidis, Yannis -- Bittig, Thomas -- Julicher, Frank -- Gonzalez-Gaitan, Marcos -- New York, N.Y. -- Science. 2007 Jan 26;315(5811):521-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauer Strasse 108, 01307 Dresden, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17255514" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Animals, Genetically Modified
;
Diffusion
;
Drosophila Proteins/*metabolism
;
Drosophila melanogaster/growth & development/*metabolism
;
Endocytosis
;
Fluorescence Recovery After Photobleaching
;
Kinetics
;
Mathematics
;
Proto-Oncogene Proteins/*metabolism
;
Recombinant Fusion Proteins/metabolism
;
Temperature
;
Wings, Animal/*growth & development/*metabolism
;
Wnt1 Protein
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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