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    Abnormal chromosome behavior in Neurospora mutants defective in DNA methylation (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-12-10
    Description: The function and regulation of DNA methylation in eukaryotes remain unclear. Genes affecting methylation were identified in the fungus Neurospora crassa. A mutation in one gene, dim-2, resulted in the loss of all detectable DNA methylation. Abnormal segregation of the methylation defects in crosses led to the discovery that the methylation mutants frequently generate strains with extra chromosomes or chromosomal parts. Starvation for S-adenosylmethionine, the presumed methyl group donor for DNA methylation, also produced aneuploidy. These results suggest that DNA methylation plays a role in the normal control of chromosome behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Foss, H M -- Roberts, C J -- Claeys, K M -- Selker, E U -- GM-35690/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1993 Dec 10;262(5140):1737-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Molecular Biology, University of Oregon, Eugene 97403.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7505062" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Methylcytosine ; Aneuploidy ; Azacitidine/pharmacology ; Blotting, Southern ; Chromosomes, Fungal/*metabolism ; Crosses, Genetic ; Cytosine/*analogs & derivatives/analysis ; DNA, Fungal/chemistry/*metabolism ; Genes, Fungal ; Genetic Complementation Test ; Methionine/metabolism ; Methylation ; Mutation ; Neurospora crassa/*genetics/growth & development ; Phenotype ; S-Adenosylmethionine/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Dense nonsymmetrical DNA methylation resulting from repeat-induced point mutation in Neurospora (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-12-10
    Description: Cytosine methylation has been implicated in epigenetic control of gene expression in animals, plants, and fungi. It has been assumed that all methylation in eukaryotes is at symmetrical sequences such as CpG/GpC, because this can explain perpetuation of methylation states. Here the bisulfite genomic sequencing method was used to examine methylation in DNA from a Neurospora gene exposed to repeat-induced point mutation. 5-Methylcytosine was not limited to symmetrical sites and individual molecules showed different patterns and amounts of modification. The methylation extended beyond the mutated region and even beyond the edge of the duplicated segment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Selker, E U -- Fritz, D Y -- Singer, M J -- GM 35690/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1993 Dec 10;262(5140):1724-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Molecular Biology, University of Oregon, Eugene 97403.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8259516" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Methylcytosine ; Base Sequence ; Blotting, Southern ; Cytosine/*analogs & derivatives/analysis ; DNA Restriction Enzymes ; DNA, Fungal/chemistry/*metabolism ; DNA-Binding Proteins/genetics ; Fungal Proteins/genetics ; Genes, Fungal ; Glutamate Dehydrogenase/*genetics ; Methylation ; Molecular Sequence Data ; Neurospora crassa/enzymology/*genetics ; Point Mutation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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    PAPER CURRENT
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